There are 4 ways to get from Biloxi to Florida Keys by plane, bus (Greyhound), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Gulfport-Biloxi Regional Airport
best- Fly from Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW)plane GPT - EYW
8h 31m$178–467Drive 900.8 mi
cheapest- Drive from Biloxi to Florida Keyscar 900.8 mi
16h 8m$160–230Bus
- Take the bus from Biloxi to Miamibus Houston
- Take the bus from Miami Airport Station to Big Pine Keybus Greyhound US0720s
23h 21m$176–228Bus to Mobile Regional Airport, fly
- Take the bus from Biloxi Transit Center to Mobile Bus Stationbus
- Fly from Mobile Regional Airport (MOB) to Key West International Airport (EYW)plane MOB - EYW
9h 8m$170–458
Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW) flights
Comparing Your Travel Options
The cheapest way to get from Biloxi to Florida Keys is to drive which costs $150 - $230 and takes 16h 8m.
The fastest way to get from Biloxi to Florida Keys is to fly which takes 8h 31m and costs $170 - $470.
No, there is no direct bus from Biloxi to Florida Keys. However, there are services departing from Biloxi and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 23h 21m.
The distance between Biloxi and Florida Keys is 642 miles. The road distance is 906 miles.
The best way to get from Biloxi to Florida Keys without a car is to bus which takes 23h 21m and costs $170 - $230.
It takes approximately 8h 31m to get from Biloxi to Florida Keys, including transfers.
Biloxi to Florida Keys bus services, operated by Omnibus Express, depart from Biloxi station.
The best way to get from Biloxi to Florida Keys is to fly which takes 8h 31m and costs $170 - $470. Alternatively, you can bus, which costs $170 - $230 and takes 23h 21m.
Biloxi to Florida Keys bus services, operated by Omnibus Express, arrive at Miami station.
Yes, the driving distance between Biloxi to Florida Keys is 906 miles. It takes approximately 16h 8m to drive from Biloxi to Florida Keys.
What companies run services between Biloxi, MS, USA and Florida Keys, FL, USA?
Delta, American Airlines, and United Airlines fly from Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a bus from Biloxi to Florida Keys via Miami, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 23h 21m.
- Website
- delta.com
Flights from Gulfport-Biloxi Regional Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 36m
- When
- Every day
- Estimated price
- $65–330
Flights from Mobile Regional Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 28m
- When
- Every day
- Estimated price
- $60–320
- Website
- aa.com
Flights from Gulfport-Biloxi Regional Airport to Key West International Airport via Charlotte
- Ave. Duration
- 5h 16m
- When
- Every day
- Estimated price
- $75–370
Flights from Gulfport-Biloxi Regional Airport to Key West International Airport via Dallas/Ft.Worth
- Ave. Duration
- 10h 36m
- When
- Every day
- Estimated price
- $90–400
Flights from Mobile Regional Airport to Key West International Airport via Charlotte
- Ave. Duration
- 7h 26m
- When
- Every day
- Estimated price
- $75–360
- Website
- united.com
Flights from Gulfport-Biloxi Regional Airport to Key West International Airport via Houston
- Ave. Duration
- 7h 42m
- When
- Saturday
- Estimated price
- $75–360
Flights from Mobile Regional Airport to Key West International Airport via Houston
- Ave. Duration
- 5h 42m
- When
- Saturday
- Estimated price
- $80–370
- Phone
- +1 800-923-1799
- [email protected]
- Website
- Omnibus Express
Bus from Biloxi to Miami
- Ave. Duration
- 17h 7m
- Frequency
- Once daily
- Estimated price
- $130–180
- Schedules at
- Omnibus Express
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 5 times a day
- Estimated price
- $23–35
- Website
- Greyhound
Bus from Biloxi Transit Center to Mobile Bus Station
- Ave. Duration
- 55 min
- Frequency
- 4 times a day
- Estimated price
- $10–16
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Biloxi Transit Center to Mobile Bus Station
- Ave. Duration
- 55 min
- Frequency
- Twice daily
- Estimated price
- $8–14
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
There are 23+ hotels available in Florida Keys.