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How to get fromBoston to Mayo Clinicby ferry, plane, train, bus, bus (Flixbus, Greyhound), or car

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There are 10 ways to get from Boston to Mayo Clinic by ferry, plane, train, bus, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Ferry to Boston Logan Airport, fly to Rochester

    best
    1. Take the ferry from Long Wharf to Logan Airport Ferry Terminalferry ferry
    2. Fly from Boston Logan Airport (BOS) to Rochester (RST)plane plane BOS - RST
    8h 6m
    $115–600

  2. Train, bus via Madison

    1. Take the train from Boston to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    32h 8m
    $637–993

  3. Bus

    1. Take the bus from Boston to New York Midtownbus bus
    2. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    35h 13m
    $267–403

  4. Drive  1,326.6 mi

    1. Drive from Boston to Mayo Cliniccar car 1,326.6 mi
    22h 30m
    $243–350

  5. Train to Theodore Francis Green State Airport, fly to Rochester

    1. Take the train from South Station to TF Green Airporttrain train
    2. Fly from Theodore Francis Green State Airport (PVD) to Rochester (RST)plane plane PVD - RST
    9h 20m
    $121–656

  6. Ferry to Boston Logan Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the ferry from Long Wharf to Logan Airport Ferry Terminalferry ferry
    2. Fly from Boston Logan Airport (BOS) to Minneapolis–Saint Paul International Airport (MSP)plane plane BOS - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h
    $444–1,060

  7. Train to Theodore Francis Green State Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from South Station to TF Green Airporttrain train
    2. Fly from Theodore Francis Green State Airport (PVD) to Minneapolis–Saint Paul International Airport (MSP)plane plane PVD - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 57m
    $200–766

  8. Bus to Bradley International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Boston to Hartfordbus bus
    2. Fly from Bradley International Airport (BDL) to Minneapolis–Saint Paul International Airport (MSP)plane plane BDL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 59m
    $202–737

  9. Ferry to Boston Logan Airport, fly to Dane County Regional Airport-Truax Field, bus

    1. Take the ferry from Long Wharf to Logan Airport Ferry Terminalferry ferry
    2. Fly from Boston Logan Airport (BOS) to Dane County Regional Airport-Truax Field (MSN)plane plane BOS - MSN
    3. Take the bus from Madison to Rochesterbus bus
    10h 58m
    $196–787

  10. Train, bus

    1. Take the train from Boston to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    33h 26m
    $810–1,253

Boston to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration32h 8mAverage Duration
Ticket$637Cheapest Price
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Comparing Your Travel Options

Map of how to get from Boston to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,096.9 mi
  • Duration: 8h 6m

What companies run services between Boston, MA, USA and Mayo Clinic, MN, USA?

You can take a bus from Boston to Mayo Clinic via New York Midtown, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 35h 13m.

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