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How to get fromBoston to Mayo Clinicby plane, train, bus, bus (Flixbus, Greyhound), or car

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There are 7 ways to get from Boston to Mayo Clinic by plane, train, bus, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Boston Logan Airport to Rochester

    best
    1. Fly from Boston Logan Airport (BOS) to Rochester (RST)plane plane BOS - RST
    6h 16m
    $109–547

  2. Train, bus via Madison

    1. Take the train from Boston to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    32h 8m
    $344–716

  3. Bus

    1. Take the bus from Boston to New York Midtownbus bus
    2. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    35h 13m
    $265–400

  4. Drive  1,326.6 mi

    1. Drive from Boston to Mayo Cliniccar car 1,326.6 mi
    22h 31m
    $243–350

  5. Fly Boston Logan Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Boston Logan Airport (BOS) to Minneapolis–Saint Paul International Airport (MSP)plane plane BOS - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 1m
    $433–1,055

  6. Train to Theodore Francis Green State Airport, fly to Rochester

    1. Take the train from South Station to TF Green Airporttrain train
    2. Fly from Theodore Francis Green State Airport (PVD) to Rochester (RST)plane plane PVD - RST
    8h 49m
    $111–536

  7. Train, bus

    1. Take the train from Boston to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    33h 26m
    $397–866

Boston to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration32h 8mAverage Duration
Ticket$344Cheapest Price
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Questions & Answers

Map of how to get from Boston to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,094.2 mi
  • Duration: 6h 16m

What companies run services between Boston, MA, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from Boston Logan Airport (BOS) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Boston to Mayo Clinic via New York Midtown, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 35h 13m.

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