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How to get fromBoston to Saint Charlesby plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus (Flixbus, Greyhound)

Find Transport to Saint Charles

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There are 5 ways to get from Boston to Saint Charles by plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    3h 57m
    $368–847

  2. Bus

    cheapest
    1. Take the bus from Boston to Newark Penn Stationbus bus Greyhound US0235 / ...
    2. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus Greyhound US0421
    30h 48m
    $192–367

  3. Train (Amtrak)

    1. Take the train from Boston to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    29h 33m
    $430–855

  4. Drive 1,164.6 mi

    1. Drive from Boston to Saint Charlescar car 1,164.6 mi
    20h 42m
    $213–307

  5. Bus via Alewife

    1. Take the bus from Cambridge to Newark Penn Stationbus bus FlixBus 2619
    2. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus Greyhound US0421
    32h 44m
    $196–371

Boston to Saint Charles by train and bus (Amtrak)

Calendar7Weekly Services
Duration29h 33mAverage Duration
Ticket$430Cheapest Price
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Questions & Answers

Map of how to get from Boston to Saint Charles.ExpandLaunch map view
  • Distance: 1,057.7 mi
  • Duration: 3h 57m

What companies run services between Boston, MA, USA and Saint Charles, MO, USA?

American Airlines, Southwest Airlines, and United Airlines fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a train from Boston to 4375 Rider Trail North Sb via Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 29h 33m.

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