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How to get fromBristol to St. Louisby plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Greyhound, Flixbus, Amtrak)

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There are 7 ways to get from Bristol to St. Louis by plane, bus, train, car, bus (Greyhound, Flixbus), or bus (Greyhound, Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Tri-Cities Regional Tn/Va Airport

    best
    1. Fly from Tri-Cities Regional Tn/Va Airport (TRI) to Lambert–St. Louis International Airport (STL)plane plane TRI - STL
    5h 17m
    $150–609

  2. Drive 545.5 mi

    cheapest
    1. Drive from Bristol to St. Louiscar car 545.5 mi
    10h 28m
    $100–144

  3. Bus, train

    1. Take the bus from Bristol Exit 5 Park & Ride Lot to Wytheville Rural King Parking Lotbus bus
    2. Take the bus from Wytheville to Ashlandbus bus
    3. Take the train from Ashland Amtrak Station to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    19h 55m
    $192–375

  4. Drive to Mcghee Tyson Airport, fly

    1. Drive from Bristol to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Lambert–St. Louis International Airport (STL)plane plane TYS - STL
    6h
    $136–736

  5. Drive to Greenville–Spartanburg International Airport, fly

    1. Drive from Bristol to Greenville–Spartanburg International Airport (GSP)car car
    2. Fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL)plane plane GSP - STL
    7h 5m
    $140–692

  6. Bus

    1. Take the bus from Bristol Exit 5 Park & Ride Lot to Christiansburgbus bus
    2. Take the bus from Exit 118 - Park and Ride to 3rd St Station Slip Dbus bus Swb
    3. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    21h 16m
    $149–270

  7. Bus via Carbondale

    1. Take the bus from Bristol Exit 5 Park & Ride Lot to Christiansburgbus bus
    2. Take the bus from Exit 118 - Park and Ride to 3rd St Station Slip Dbus bus Swb
    3. Take the bus from Roanoke Bus Stop to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    5. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    21h 26m
    $149–280

Tri-Cities Regional Tn/Va Airport (TRI) to Lambert–St. Louis International Airport (STL) flights

Calendar70Weekly Planes
Duration5h 9mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Bristol to St. Louis.ExpandLaunch map view
  • Distance: 492.2 mi
  • Duration: 5h 17m

What companies run services between Bristol, TN, USA and St. Louis, MO, USA?

American Airlines, Delta, and United Airlines fly from Tri-Cities Regional Tn/Va Airport (TRI) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a vehicle from Bristol to St Louis Bus Station via Bristol Exit 5 Park & Ride Lot, Christiansburg, Exit 118 - Park and Ride, Roanoke Bus Stop, and Nashville Bus Station in around 21h 16m.

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