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How to get fromBrussels to Iserniaby plane, train, train (Eurostar, Trenitalia), bus, car, or car train

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There are 12 ways to get from Brussels to Isernia by plane, train, train (Eurostar, Trenitalia), bus, car, or car train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Brussels Airport to Fiumicino International Airport, train

    best
    1. Fly from Brussels Airport (BRU) to Fiumicino International Airport (FCO)plane plane BRU - FCO
    2. Take the train from Roma Termini to Iserniatrain train
    8h 1m
    €69–231

  2. Train to Brussels South Charleroi Airport, fly to Abruzzo Airport, bus

    cheapest
    1. Take the train from Bruxelles-Central to Charleroi-Centraltrain train
    2. Fly from Brussels South Charleroi Airport (CRL) to Abruzzo Airport (PSR)plane plane CRL - PSR
    3. Take the bus from Pescara to Iserniabus bus
    10h 25m
    €62–305

  3. Train

    1. Take the train from Brussel-Zuid / Bruxelles-Midi to Chambery Challes Les Eauxtrain train
    2. Take the train from Chambery Challes Les Eaux to Milano Centraletrain train Fr
    3. Take the train from Milano Centrale to Roma Terminitrain train
    4. Take the train from Roma Termini to Iserniatrain train Re
    15h 18m
    €369–649

  4. Bus

    1. Take the bus from Bruxelles - Rue du Progrès to Casello - A1 Ingresso Caianellobus bus
    2. Take the bus from Casello - A1 Ingresso Caianello to Iserniabus bus 6
    22h 41m

  5. Drive 1,593.7 km

    1. Drive from Brussels to Iserniacar car 1,593.7 km
    15h 45m
    €248–359

  6. Fly Brussels Airport to Naples Airport, train

    1. Fly from Brussels Airport (BRU) to Naples Airport (NAP)plane plane BRU - NAP
    2. Take the train from Caserta to Iserniatrain train
    8h 15m
    €79–217

  7. Train to Brussels South Charleroi Airport, fly to Naples Airport, train

    1. Take the train from Bruxelles-Central to Charleroi-Centraltrain train
    2. Fly from Brussels South Charleroi Airport (CRL) to Naples Airport (NAP)plane plane CRL - NAP
    3. Take the train from Caserta to Iserniatrain train
    9h 23m
    €76–297

  8. Train to Amsterdam Airport Schiphol, fly to Naples Airport, train

    1. Take the train from Brussel-Zuid to Schiphol Airport Train Stationtrain train
    2. Fly from Amsterdam Airport Schiphol (AMS) to Naples Airport (NAP)plane plane AMS - NAP
    3. Take the train from Caserta to Iserniatrain train
    10h 7m
    €113–316

  9. Train to Brussels South Charleroi Airport, fly to Fiumicino International Airport, train

    1. Take the train from Bruxelles-Central to Charleroi-Centraltrain train
    2. Fly from Brussels South Charleroi Airport (CRL) to Fiumicino International Airport (FCO)plane plane CRL - FCO
    3. Take the train from Roma Termini to Iserniatrain train
    9h 19m
    €91–311

  10. Fly Brussels Airport to Florence Peretola Airport, train

    1. Fly from Brussels Airport (BRU) to Florence Peretola Airport (FLR)plane plane BRU - FLR
    2. Take the train from Firenze S.M.N. to Roma Terminitrain train
    3. Take the train from Roma Termini to Iserniatrain train
    9h 38m
    €114–331

  11. Bus via Bologna

    1. Take the bus from Brussels-North Station to Bolognabus bus
    2. Take the bus from Bologna Centrale to Iserniabus bus 433
    26h 34m

  12. Drive, car train

    1. Drive from Brussels to Fuldacar car
    2. Take the cartrain from Fulda to Villach Hbfcartrain train
    3. Drive from Villach Hbf to Iserniacar car
    23h 19m
    €294–409

Brussels to Isernia by train

Calendar2Weekly Trains
Duration15h 18mAverage Duration
Ticket€369Cheapest Price
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Questions & Answers

Map of how to get from Brussels to Isernia.ExpandLaunch map view
  • Distance: 1,403.3 km
  • Duration: 8h 1m

What companies run services between Brussels, Belgium and Isernia, Italy?

You can take a train from Brussel-Zuid / Bruxelles-Midi to Isernia via Chambery Challes Les Eaux, Milano Centrale, and Roma Termini in around 15h 18m. Alternatively, you can take a bus from Bruxelles - Rue du Progrès to Isernia via Casello - A1 Ingresso Caianello in around 22h 41m.

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