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How to get fromBuffalo Airport (BUF) to Knoxvilleby plane, bus, car, bus (Flixbus), or train

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There are 7 ways to get from Buffalo Airport (BUF) to Knoxville by plane, bus, car, bus (Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    4h 6m
    $234–1,011

  2. Drive 687.6 mi

    cheapest
    1. Drive from Buffalo Airport (BUF) to Knoxvillecar car 687.6 mi
    11h 35m
    $126–182

  3. Bus

    1. Take the bus from Buffalo to New Yorkbus bus Adt N801 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    21h 30m
    $240–498

  4. Fly to Nashville, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Nashville (BNA)plane plane BUF - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 44m
    $126–568

  5. Bus via New York

    1. Take the bus from Buffalo Niagara International Airport to New York Midtownbus bus FlixBus N2686 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    21h 51m
    $253–367

  6. Bus, train via Albany

    1. Take the bus from Buffalo to Rochesterbus bus
    2. Take the train from Rochester to Albany-Rensselaer Amtrak Stationtrain train
    3. Take the train from Albany-Rensselaer Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    23h 25m
    $256–518

  7. Bus, train

    1. Take the bus from Buffalo to Rochesterbus bus
    2. Take the train from Rochester to New York Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    23h 42m
    $301–563

Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) flights

Calendar90Weekly Planes
Duration4h 50mAverage Duration
Ticket$178Cheapest Price
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Questions & Answers

Map of how to get from Buffalo Airport (BUF) to Knoxville.ExpandLaunch map view
  • Distance: 579.5 mi
  • Duration: 4h 6m

What companies run services between Buffalo Airport (BUF), USA and Knoxville, TN, USA?

Delta, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Buffalo to Knoxville via New York, 47-50 Sts-Rockefeller Ctr, East Broadway, New York, and Knoxville in around 21h 30m.

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