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How to get fromBuffalo Airport (BUF) to St. Louisby plane, train (Amtrak), bus (Greyhound), or car

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There are 5 ways to get from Buffalo Airport (BUF) to St. Louis by plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    4h 23m
    $146–733

  2. Bus via Youngstown

    cheapest
    1. Take the bus from Buffalo, NY to Youngstown, OHbus bus
    2. Take the bus from Youngstown Bus Stop to Pittsburgh Intermodal Stationbus bus
    3. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus
    20h 45m
    $119–282

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    18h 13m
    $280–603

  4. Drive 741.9 mi

    1. Drive from Buffalo Airport (BUF) to St. Louiscar car 741.9 mi
    12h 39m
    $136–196

  5. Bus

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    23h 5m
    $142–428

Buffalo Airport (BUF) to St. Louis by bus, taxi, and train (Amtrak)

Calendar14Weekly Services
Duration18h 13mAverage Duration
Ticket$280Cheapest Price
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Questions & Answers

Map of how to get from Buffalo Airport (BUF) to St. Louis.ExpandLaunch map view
  • Distance: 686.7 mi
  • Duration: 4h 23m

What companies run services between Buffalo Airport (BUF), USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from BNIA Driveway & BNIA Terminal to St. Louis via Washington Street & Eagle Street, Buffalo Depew Station, and Chicago Union Station in around 18h 13m.

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