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How to get fromBuffalo Depew Station to Bostonby plane, ferry, train (Amtrak), bus (Greyhound), car, or bus (Flixbus)

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There are 5 ways to get from Buffalo Depew Station to Boston by plane, ferry, train (Amtrak), bus (Greyhound), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, ferry

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Provincetown Municipal Airport (PVC)plane plane BUF - PVC
    2. Take the ferry from MacMillan Pier, Provincetown, MA to World Trade Center Pier, Boston, MAferry ferry
    6h 12m
    $165–537
  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Buffalo to Bostonbus bus Greyhound US0171
    12h 26m
    $74–124
  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Bostontrain train Lake Shore Limited
    11h 27m
    $120–290
  4. Drive  446.6 mi

    1. Drive from Buffalo Depew Station to Bostoncar car 446.6 mi
    7h 51m
    $82–118
  5. Bus via Ithaca (Flixbus)

    1. Take the bus from Buffalo to Ithacabus bus FlixBus 2685 / ...
    2. Take the bus from Ithaca to Bostonbus bus FlixBus 2691
    15h 1m
    $83–129

Buffalo Depew Station to Boston by train (Amtrak)

Calendar7Weekly Trains
Duration11h 27mAverage Duration
Ticket$120Cheapest Price
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Comparing Your Travel Options

What companies run services between Buffalo Depew Station, NY, USA and Boston, MA, USA?

Amtrak operates a train from Buffalo Depew Station to Boston once daily. Tickets cost $120–290 and the journey takes 11h 27m. Alternatively, Greyhound USA operates a bus from Buffalo to Boston once daily. Tickets cost $70–120 and the journey takes 10h 5m.

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