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How to get fromBuffalo Depew Station to Charlestonby plane, train (Amtrak), car, train, or bus

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There are 6 ways to get from Buffalo Depew Station to Charleston by plane, train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Charleston International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Charleston International Airport (CHS)plane plane BUF - CHS
    5h 26m
    $116–569

  2. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    23h 31m
    $385–803

  3. Drive 862.9 mi

    1. Drive from Buffalo Depew Station to Charlestoncar car 862.9 mi
    14h 44m
    $158–228

  4. Train to Rochester, fly to Charleston International Airport

    1. Take the train from Buffalo Depew Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Charleston International Airport (CHS)plane plane ROC - CHS
    5h 41m
    $178–930

  5. Fly Buffalo Niagara International Airport to Hilton Head Airport, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Hilton Head Airport (HHH)plane plane BUF - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 10m
    $132–594

  6. Bus, train

    1. Take the bus from Buffalo to Newark Penn Stationbus bus FlixBus N2686 / ...
    2. Take the train from Newark Penn Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    26h 35m
    $288–598

Buffalo Depew Station to Charleston by bus and train

Calendar14Weekly Services
Duration26h 35mAverage Duration
Ticket$288Cheapest Price
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Questions & Answers

Map of how to get from Buffalo Depew Station to Charleston.ExpandLaunch map view
  • Distance: 715.8 mi
  • Duration: 5h 26m

What companies run services between Buffalo Depew Station, NY, USA and Charleston, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Charleston International Airport (CHS) hourly. Alternatively, you can take a train from Buffalo Depew Station to Charleston via Ny Moynihan Train Hall At Penn Station and Charleston Amtrak Station in around 23h 31m.

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