There are 5 ways to get from Buffalo Depew Station to Chicago by plane, train (Amtrak), bus (Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Chicago Midway International Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane BUF - MDW
2h 24m$116–452Bus (Greyhound)
cheapest- Take the bus from Buffalo to Cleveland Bus Stationbus Greyhound US0171 / ...
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus Greyhound US0164
13h 47m$84–174Train (Amtrak)
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain Lake Shore Limited
10h 33m$170–350Drive 534.3 mi
- Drive from Buffalo Depew Station to Chicagocar 534.3 mi
9h 5m$98–141Fly to Chicago O'Hare International Airport
- Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane BUF - ORD
2h 47m$166–392
Buffalo Depew Station to Chicago by train (Amtrak)
Questions & Answers
The cheapest way to get from Buffalo Depew Station to Chicago is to bus which costs $80 - $180 and takes 13h 47m.
The fastest way to get from Buffalo Depew Station to Chicago is to fly which takes 2h 24m and costs $110 - $460.
No, there is no direct bus from Buffalo Depew Station station to Chicago station. However, there are services departing from Dick Road & AMTRAK Station and arriving at Chicago Bus Station via Walden Avenue & Thruway Transit Center, Buffalo and Cleveland Bus Station. The journey, including transfers, takes approximately 13h 47m.
Yes, there is a direct train departing from Buffalo Depew Station station and arriving at Chicago Union Station station. Services depart twice daily, and operate every day. The journey takes approximately 10h 33m.
The distance between Buffalo Depew Station and Chicago is 484 miles. The road distance is 537.4 miles.
The best way to get from Buffalo Depew Station to Chicago without a car is to train which takes 10h 33m and costs $170 - $350.
It takes approximately 2h 24m to get from Buffalo Depew Station to Chicago, including transfers.
Buffalo Depew Station to Chicago bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo Depew Station to Chicago train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo Depew Station to Chicago is to fly which takes 2h 24m and costs $110 - $460. Alternatively, you can train, which costs $170 - $350 and takes 10h 33m, you could also bus, which costs $80 - $180 and takes 13h 47m.
What companies run services between Buffalo Depew Station, NY, USA and Chicago, IL, USA?
Southwest Airlines and Delta fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW) 5 times a day. Alternatively, Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $170–350 and the journey takes 10h 33m.
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 36m
- When
- Every day
- Estimated price
- $75–440
- Website
- united.com
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 1m
- When
- Every day
- Estimated price
- $65–380
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport via Washington Dulles
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $95–470
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 2h 5m
- When
- Every day
- Estimated price
- $65–380
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport via Detroit
- Ave. Duration
- 3h 44m
- When
- Every day
- Estimated price
- $75–440
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Buffalo Depew Station to Chicago Union Station
- Ave. Duration
- 10h 33m
- Frequency
- Twice daily
- Estimated price
- $170–350
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Buffalo to Cleveland Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $30–60
- Website
- https://www.greyhound.com/
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 25m
- Frequency
- Twice daily
- Estimated price
- $50–110
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Buffalo Depew Station to Chicago bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Chicago is 1h behind Buffalo Depew Station. It is currently 11:13 PM in Buffalo Depew Station and 10:13 PM in Chicago.
Buffalo Depew Station to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Buffalo Depew Station to Chicago is 537 miles. It takes approximately 9h 5m to drive from Buffalo Depew Station to Chicago.
Book your Buffalo Depew Station to Chicago train tickets online with Omio.
There are 1243+ hotels available in Chicago.





