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How to get fromBuffalo Depew Station to Great Smoky Mountainsby plane, car, train, or bus

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There are 10 ways to get from Buffalo Depew Station to Great Smoky Mountains by plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Mcghee Tyson Airport, drive

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 48m
    $194–983

  2. Fly Buffalo Niagara International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Asheville Regional Airport (AVL)plane plane BUF - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    6h 18m
    $113–509

  3. Train, bus, drive

    1. Take the train from Buffalo to New York Penn Stationtrain train
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    24h 10m
    $227–413

  4. Train, bus, drive via Greensboro

    1. Take the train from Buffalo Depew Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    25h 43m
    $320–678

  5. Drive 726.6 mi

    1. Drive from Buffalo Depew Station to Great Smoky Mountainscar car 726.6 mi
    12h 56m
    $133–192

  6. Fly Buffalo Niagara International Airport to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane BUF - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    6h 22m
    $139–352

  7. Fly Buffalo Niagara International Airport to Nashville, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Nashville (BNA)plane plane BUF - BNA
    2. Drive from Nashville-Airport-BNA to Great Smoky Mountainscar car
    6h 40m
    $149–632

  8. Train to Rochester, fly to Mcghee Tyson Airport, drive

    1. Take the train from Buffalo Depew Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Mcghee Tyson Airport (TYS)plane plane ROC - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 42m
    $236–1,193

  9. Bus, drive

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus
    2. Take the bus from New York to Knoxvillebus bus Nyc
    3. Drive from Knoxville to Great Smoky Mountainscar car
    25h 39m
    $170–417

  10. Bus, drive via Farragut

    1. Take the bus from Buffalo to New York Midtownbus bus
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    26h 12m
    $184–255

Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) flights

Calendar90Weekly Planes
Duration4h 50mAverage Duration
Ticket$178Cheapest Price
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Questions & Answers

Map of how to get from Buffalo Depew Station to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 629.4 mi
  • Duration: 5h 48m

What companies run services between Buffalo Depew Station, NY, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Buffalo Depew Station to Great Smoky Mountains. However, you can take the taxi to Buffalo-Airport-BUF airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a train from Buffalo to Great Smoky Mountains via Penn Station, 34 St-Herald Sq, East Broadway, New York, NY, and Knoxville, TN in around 24h 10m.

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