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How to get fromBuffalo Depew Station to Harrisburg, Paby plane, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

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There are 6 ways to get from Buffalo Depew Station to Harrisburg, Pa by plane, bus (Flixbus), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Harrisburg International Airport (MDT)plane plane BUF - MDT
    4h 12m
    $75–419

  2. Drive 274.4 mi

    cheapest
    1. Drive from Buffalo Depew Station to Harrisburg, Pacar car 274.4 mi
    5h 31m
    $51–73

  3. Bus via Sandy

    1. Take the bus from Buffalo to DuBoisbus bus
    2. Take the bus from DuBois to State Collegebus bus
    3. Take the bus from State College Regional Airport to Harrisburg Bus Stationbus bus
    11h 52m
    $106–203

  4. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Harrisburgtrain train Keystone Service / ...
    12h 23m
    $194–412

  5. Fly to Philadelphia International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Philadelphia International Airport (PHL)plane plane BUF - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    5h 5m
    $122–590

  6. Bus

    1. Take the bus from Buffalo to Scranton Bus Stationbus bus Greyhound US0215 / ...
    2. Take the bus from Scranton, Pa to Harrisburg, Pabus bus 771
    11h 57m
    $68–159

Buffalo Depew Station to Harrisburg, Pa by bus

Calendar7Weekly Buses
Duration11h 52mAverage Duration
Ticket$106Cheapest Price
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Questions & Answers

Map of how to get from Buffalo Depew Station to Harrisburg, Pa.ExpandLaunch map view
  • Distance: 229.1 mi
  • Duration: 4h 12m

What companies run services between Buffalo Depew Station, NY, USA and Harrisburg, Pa, PA, USA?

United Airlines, American Airlines, and Delta fly from Buffalo Niagara International Airport (BUF) to Harrisburg International Airport (MDT) hourly. Alternatively, you can take a bus from Dick Road & AMTRAK Station to Harrisburg Bus Station via Walden Avenue & Thruway Transit Center, Ellicott Street & MTC Static, Buffalo, DuBois, and State College Regional Airport in around 11h 52m.

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