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How to get fromBuffalo Depew Station to Indianapolisby plane, train, bus, bus (Greyhound), car, train (Amtrak), or bus (Flixbus)

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There are 7 ways to get from Buffalo Depew Station to Indianapolis by plane, train, bus, bus (Greyhound), car, train (Amtrak), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND)plane plane BUF - IND
    4h 38m
    $126–719

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Columbus - Mound Stbus bus Buffalo
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus Greyhound US0421
    14h 22m
    $67–139

  3. Train, bus

    1. Take the train from Buffalo Depew Station to Toledotrain train Lake Shore Limited
    2. Take the bus from Toledo to Indianapolis, INbus bus Detroit
    10h 39m
    $116–259

  4. Drive 499 mi

    1. Drive from Buffalo Depew Station to Indianapoliscar car 499 mi
    8h 37m
    $92–132

  5. Train to Rochester, fly

    1. Take the train from Buffalo Depew Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Indianapolis (IND)plane plane ROC - IND
    6h 44m
    $157–879

  6. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    16h 27m
    $231–477

  7. Bus via Pittsburgh

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to Indianapolisbus bus FlixBus N2642 / ...
    17h 52m
    $109–324

Buffalo Depew Station to Indianapolis by train and bus

Calendar7Weekly Services
Duration10h 39mAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

Map of how to get from Buffalo Depew Station to Indianapolis.ExpandLaunch map view
  • Distance: 469.3 mi
  • Duration: 4h 38m

What companies run services between Buffalo Depew Station, NY, USA and Indianapolis, IN, USA?

Delta, Southwest Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND) hourly. Alternatively, you can take a bus from Dick Road & AMTRAK Station to Indianapolis Union Station via Walden Avenue & Thruway Transit Center, Buffalo, NY, and Columbus in around 14h 22m.

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