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How to get fromBuffalo Depew Station to Louisvilleby plane, train, bus, car, or bus (Greyhound)

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There are 7 ways to get from Buffalo Depew Station to Louisville by plane, train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Louisville International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    5h 9m
    $135–720

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus bus Buffalo
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Louisville, KY Bus Stationbus bus Cleveland
    14h 7m
    $56–149

  3. Train, bus

    1. Take the train from Buffalo Depew Station to Cleveland Amtraktrain train Lake Shore Limited
    2. Take the bus from Cleveland Ohio Greyhound Station to Louisville, KY Bus Stationbus bus Cleveland
    11h 36m
    $96–206

  4. Drive 534.4 mi

    1. Drive from Buffalo Depew Station to Louisvillecar car 534.4 mi
    9h 3m
    $98–141

  5. Fly Buffalo Niagara International Airport to Blue Grass Airport, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Blue Grass Airport (LEX)plane plane BUF - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 10m
    $207–1,036

  6. Train to Rochester, fly to Louisville International Airport

    1. Take the train from Buffalo Depew Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Louisville International Airport (SDF)plane plane ROC - SDF
    6h 51m
    $406–780

  7. Bus via Reading

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Cincinnati Bus Stationbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    15h 52m
    $79–184

Buffalo Depew Station to Louisville by train, foot, and bus

Calendar14Weekly Services
Duration11h 36mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Buffalo Depew Station to Louisville.ExpandLaunch map view
  • Distance: 502.3 mi
  • Duration: 5h 9m

What companies run services between Buffalo Depew Station, NY, USA and Louisville, KY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a bus from Dick Road & AMTRAK Station to Louisville, KY Bus Station via Walden Avenue & Thruway Transit Center, Buffalo, NY, and Robert K Pfaff Transit Center - Akron in around 14h 7m.

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