There are 5 ways to get from Buffalo Depew Station to Salem by plane, train, train (Amtrak), bus (Greyhound), car, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly, train
best- Fly from Buffalo Niagara International Airport (BUF) to Boston Logan Airport (BOS)plane BUF - BOS
- Take the train from Chelsea to Salemtrain
2h 56m$82–430Bus (Greyhound)
cheapest- Take the bus from Buffalo to Bostonbus Greyhound US0171
14h 17m$76–154Train (Amtrak)
- Take the train from Buffalo Depew Station to Bostontrain Lake Shore Limited
12h 30m$157–329Drive 460.4 mi
- Drive from Buffalo Depew Station to Salemcar 460.4 mi
8h 11m$84–122Bus via Ithaca (Flixbus)
- Take the bus from Buffalo to Ithacabus FlixBus 2685 / ...
- Take the bus from Ithaca to Bostonbus FlixBus 2691
16h 7m$87–157
Buffalo Depew Station to Salem by train and subway (Amtrak)
Questions & Answers
The cheapest way to get from Buffalo Depew Station to Salem is to bus which costs $75 - $160 and takes 14h 17m.
The fastest way to get from Buffalo Depew Station to Salem is to fly and train which takes 2h 56m and costs $80 - $430.
No, there is no direct bus from Buffalo Depew Station station to Salem. However, there are services departing from Dick Road & AMTRAK Station and arriving at Washington St @ New Derby St via Walden Avenue & Thruway Transit Center, Buffalo, Summer St @ Atlantic Ave and Congress St @ Haymarket Sta. The journey, including transfers, takes approximately 14h 17m.
No, there is no direct train from Buffalo Depew Station station to Salem. However, there are services departing from Buffalo Depew Station and arriving at Salem via Back Bay and North Station. The journey, including transfers, takes approximately 12h 30m.
The distance between Buffalo Depew Station and Salem is 416 miles. The road distance is 463.1 miles.
The best way to get from Buffalo Depew Station to Salem without a car is to train which takes 12h 30m and costs $150 - $330.
It takes approximately 2h 56m to get from Buffalo Depew Station to Salem, including transfers.
Buffalo Depew Station to Salem bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo Depew Station to Salem train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo Depew Station to Salem is to train which takes 12h 30m and costs $150 - $330. Alternatively, you can bus, which costs $75 - $160 and takes 14h 17m.
What companies run services between Buffalo Depew Station, NY, USA and Salem, MA, USA?
Amtrak operates a train from Buffalo Depew Station to Boston once daily. Tickets cost $150–320 and the journey takes 11h 19m. Alternatively, Greyhound USA operates a bus from Buffalo to Boston once daily. Tickets cost $70–140 and the journey takes 10h 5m.
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Boston Logan Airport
- Ave. Duration
- 1h 37m
- When
- Every day
- Estimated price
- $65–400
Flights from Buffalo Niagara International Airport to Boston Logan Airport via New York La Guardia
- Ave. Duration
- 3h 41m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $70–420
- Website
- jetblue.com
Flights from Buffalo Niagara International Airport to Boston Logan Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- $65–400
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Boston Logan Airport via Baltimore
- Ave. Duration
- 3h 40m
- When
- Monday, Thursday, and Friday
- Estimated price
- $85–470
- Website
- united.com
Flights from Buffalo Niagara International Airport to Boston Logan Airport via Newark
- Ave. Duration
- 3h 41m
- When
- Saturday
- Estimated price
- $70–420
Train from Chelsea to Salem
- Ave. Duration
- 21 min
- Frequency
- Hourly
- Estimated price
- $2–8
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $2–8
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Buffalo Depew Station to Boston
- Ave. Duration
- 11h 19m
- Frequency
- Once daily
- Estimated price
- $150–320
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Buffalo to Boston
- Ave. Duration
- 10h 5m
- Frequency
- Once daily
- Estimated price
- $70–140
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Buffalo to Ithaca
- Ave. Duration
- 3h 45m
- Frequency
- Twice daily
- Estimated price
- $25–45
- Schedules at
- Flixbus USA
Bus from Ithaca to Boston
- Ave. Duration
- 7h 55m
- Frequency
- 3 times a week
- Estimated price
- $55–95
- Schedules at
- Flixbus USA
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More Questions & Answers
Buffalo Depew Station to Salem bus services, operated by Greyhound USA, arrive at Boston station.
Buffalo Depew Station to Salem train services, operated by Amtrak, arrive at Boston station.
Yes, the driving distance between Buffalo Depew Station to Salem is 463 miles. It takes approximately 8h 11m to drive from Buffalo Depew Station to Salem.
There are 1078+ hotels available in Salem.










