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How to get fromBuffalo Depew Station to San Franciscoby plane, train (Amtrak), train, bus, or car

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There are 7 ways to get from Buffalo Depew Station to San Francisco by plane, train (Amtrak), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to San Francisco International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to San Francisco International Airport (SFO)plane plane BUF - SFO
    7h 34m
    $143–579

  2. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Richmondtrain train California Zephyr
    2d 17h
    $868–1,951

  3. Train, bus

    1. Take the train from Buffalo Depew Station to Cleveland Amtraktrain train
    2. Take the bus from Cleveland to Cambridgebus bus
    3. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    5. Take the bus from Los Angeles Union Station to San Francisco Bus Stationbus bus
    2d 21h
    $480–996

  4. Drive 2,645.4 mi

    1. Drive from Buffalo Depew Station to San Franciscocar car 2,645.4 mi
    41h 41m
    $483–698

  5. Fly Buffalo Niagara International Airport to Oakland International Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Oakland International Airport (OAK)plane plane BUF - OAK
    7h 35m
    $259–1,025

  6. Fly Buffalo Niagara International Airport to Norman Y. Mineta San José International Airport, Caltrain

    1. Fly from Buffalo Niagara International Airport (BUF) to Norman Y. Mineta San José International Airport (SJC)plane plane BUF - SJC
    2. Take the train from Santa Clara Caltrain Northbound to San Francisco Caltrain Northboundtrain train
    8h 47m
    $256–982

  7. Train to Rochester, fly to San Francisco International Airport

    1. Take the train from Buffalo Depew Station to Rochestertrain train
    2. Fly from Rochester (ROC) to San Francisco International Airport (SFO)plane plane ROC - SFO
    9h 39m
    $215–890

Buffalo Depew Station to San Francisco by train and subway (Amtrak)

Calendar7Weekly Services
Duration2d 17hAverage Duration
Ticket$868Cheapest Price
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Questions & Answers

Map of how to get from Buffalo Depew Station to San Francisco.ExpandLaunch map view
  • Distance: 2,321.7 mi
  • Duration: 7h 34m

What companies run services between Buffalo Depew Station, NY, USA and San Francisco, CA, USA?

Delta, Southwest Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to San Francisco International Airport (SFO) hourly. Alternatively, you can take a train from Buffalo Depew Station to Civic Center / UN Plaza via Chicago Union Station, Richmond, and Richmond in around 2d 17h.

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