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How to get fromBuffalo Depew Station to St. Louisby plane, train (Amtrak), bus (Greyhound), car, train, or bus

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There are 6 ways to get from Buffalo Depew Station to St. Louis by plane, train (Amtrak), bus (Greyhound), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    4h 30m
    $167–820

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Youngstown, OHbus bus
    2. Take the bus from Youngstown Bus Stop to Pittsburgh Intermodal Stationbus bus
    3. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus
    21h 12m
    $121–259

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    16h 19m
    $262–537

  4. Drive 740.5 mi

    1. Drive from Buffalo Depew Station to St. Louiscar car 740.5 mi
    12h 36m
    $136–196

  5. Train to Rochester, fly

    1. Take the train from Buffalo Depew Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    6h 23m
    $188–930

  6. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    17h 37m
    $222–437

Buffalo Depew Station to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration16h 19mAverage Duration
Ticket$262Cheapest Price
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Questions & Answers

Map of how to get from Buffalo Depew Station to St. Louis.ExpandLaunch map view
  • Distance: 690.3 mi
  • Duration: 4h 30m

What companies run services between Buffalo Depew Station, NY, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Buffalo Depew Station to St. Louis via Chicago Union Station in around 16h 19m.

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