There are 6 ways to get from Buffalo, NY to Chicago by plane, bus (Greyhound), train (Amtrak), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Buffalo Niagara International Airport to Chicago Midway International Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane BUF - MDW
3h 31m$168–343Bus (Greyhound)
cheapest- Take the bus from Buffalo to Cleveland Bus Stationbus Greyhound US0171 / ...
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus Greyhound US0164
11h 40m$81–134Train (Amtrak)
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain Lake Shore Limited
11h 58m$132–432Drive 531.1 mi
- Drive from Buffalo, NY to Chicagocar 531.1 mi
9h 3m$97–140Fly Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane BUF - ORD
3h 48m$178–333Bus to Rochester, fly to Chicago Midway International Airport
- Take the bus from Buffalo to Rochester Bus Stopbus
- Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane ROC - MDW
5h 6m$111–516
Buffalo, NY to Chicago by bus (Greyhound)
Comparing Your Travel Options
The cheapest way to get from Buffalo, NY to Chicago is to bus which costs $80 - $140 and takes 11h 40m.
The fastest way to get from Buffalo, NY to Chicago is to fly which takes 3h 31m and costs $160 - $350.
No, there is no direct bus from Buffalo, NY to Chicago station. However, there are services departing from Buffalo and arriving at Chicago Bus Station via Cleveland Bus Station. The journey, including transfers, takes approximately 11h 40m.
No, there is no direct train from Buffalo, NY to Chicago station. However, there are services departing from Buffalo and arriving at Chicago Union Station via Buffalo Depew Station. The journey, including transfers, takes approximately 11h 58m.
The distance between Buffalo, NY and Chicago is 491 miles. The road distance is 534.2 miles.
The best way to get from Buffalo, NY to Chicago without a car is to bus which takes 11h 40m and costs $80 - $140.
It takes approximately 3h 31m to get from Buffalo, NY to Chicago, including transfers.
Buffalo, NY to Chicago bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo, NY to Chicago train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo, NY to Chicago is to fly which takes 3h 31m and costs $160 - $350. Alternatively, you can bus, which costs $80 - $140 and takes 11h 40m, you could also train, which costs $130 - $440 and takes 11h 58m.
What companies run services between Buffalo, NY, USA and Chicago, IL, USA?
Southwest Airlines and Delta fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW) every 4 hours. Alternatively, you can take a bus from Buffalo to Chicago Bus Station via Cleveland Bus Station in around 11h 40m.
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 39m
- When
- Every day
- Estimated price
- $60–370
Flights from Rochester to Chicago Midway International Airport
- Ave. Duration
- 1h 48m
- When
- Every day
- Estimated price
- $80–470
Flights from Rochester to Chicago Midway International Airport via Baltimore
- Ave. Duration
- 4h 25m
- When
- Tuesday and Wednesday
- Estimated price
- $110–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Buffalo Depew Station to Chicago Union Station
- Ave. Duration
- 10h 33m
- Frequency
- Twice daily
- Estimated price
- $130–300
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Buffalo to Cleveland Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- Greyhound
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 25m
- Frequency
- Twice daily
- Estimated price
- $50–85
- Website
- Greyhound
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 20m
- Frequency
- 4 times a day
- Estimated price
- $11–19
- Website
- Greyhound
Want to know more about travelling around United States
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Booking & Getting There
Buffalo, NY to Chicago bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Chicago is 1h behind Buffalo, NY. It is currently 12:21 PM in Buffalo, NY and 11:21 AM in Chicago.
Buffalo, NY to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Buffalo, NY to Chicago is 534 miles. It takes approximately 9h 3m to drive from Buffalo, NY to Chicago.
Book your Buffalo, NY to Chicago train tickets online with Omio.
Book your Buffalo, NY to Chicago bus tickets online with Omio and FlixBus.
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