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How to get fromBuffalo to Cape Girardeauby plane, taxi, train, bus (Greyhound), car, or bus

Find Transport to Cape Girardeau

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There are 9 ways to get from Buffalo to Cape Girardeau by plane, taxi, train, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Williamson County Regional Airport, taxi

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Williamson County Regional Airport (MWA)plane plane BUF - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    7h 16m
    $217–622

  2. Fly to Cape Girardeau Municipal Airport

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Cape Girardeau Municipal Airport (CGI)plane plane BUF - CGI
    7h 33m
    $110–480

  3. Train, taxi

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carbondaletrain train
    3. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    19h 20m
    $562–983

  4. Bus via Akron

    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Cambridgebus bus
    3. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    21h 14m
    $142–275

  5. Drive  785.5 mi

    1. Drive from Buffalo to Cape Girardeaucar car 785.5 mi
    13h 45m
    $144–208

  6. Fly to Barkley Regional Airport, taxi

    1. Fly from Buffalo Niagara International Airport (BUF) to Barkley Regional Airport (PAH)plane plane BUF - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    9h 32m
    $227–622

  7. Fly to Nashville, bus, taxi

    1. Fly from Buffalo Niagara International Airport (BUF) to Nashville (BNA)plane plane BUF - BNA
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the taxi from Carbondale Intermodal Station to Cape Girardeautaxi taxi
    10h
    $219–664

  8. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    20h 45m
    $469–862

  9. Bus

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    24h 34m
    $178–412

Buffalo Niagara International Airport (BUF) to Williamson County Regional Airport (MWA) flights

Calendar19Weekly Planes
Duration6h 32mAverage Duration
Ticket$87Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Cape Girardeau.ExpandLaunch map view
  • Distance: 717.8 mi
  • Duration: 7h 16m

What companies run services between Buffalo, NY, USA and Cape Girardeau, MO, USA?

You can take a bus from Buffalo to Cape Girardeau via Akron, Cambridge, OH, St Louis Bus Station, and Cape Girardeau in around 21h 14m. Alternatively, American Airlines, Corporate Flight Management Inc, and United Airlines fly from Buffalo Niagara International Airport (BUF) to Cape Girardeau Municipal Airport (CGI) 4 times a day.

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