Rome2Rio

How to get fromBuffalo to Cape Girardeauby plane, taxi, train, bus (Greyhound), car, or bus

Find Transport to Cape Girardeau

See all options

There are 8 ways to get from Buffalo to Cape Girardeau by plane, taxi, train, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Williamson County Regional Airport, taxi

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Williamson County Regional Airport (MWA)plane plane BUF - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    8h 15m
    $242–788

  2. Fly to Cape Girardeau Municipal Airport

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Cape Girardeau Municipal Airport (CGI)plane plane BUF - CGI
    8h 22m
    $135–656

  3. Train, taxi

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carbondaletrain train
    3. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    19h 20m
    $372–826

  4. Bus via Akron

    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Cambridgebus bus
    3. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    21h 14m

  5. Drive 785.5 mi

    1. Drive from Buffalo to Cape Girardeaucar car 785.5 mi
    13h 45m
    $144–208

  6. Fly to Barkley Regional Airport, taxi

    1. Fly from Buffalo Niagara International Airport (BUF) to Barkley Regional Airport (PAH)plane plane BUF - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    9h 54m
    $252–798

  7. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    20h 45m
    $287–720

  8. Bus

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    24h 34m
    $171–447

Buffalo Niagara International Airport (BUF) to Williamson County Regional Airport (MWA) flights

Calendar26Weekly Planes
Duration7h 10mAverage Duration
Ticket$117Cheapest Price
See schedules

Questions & Answers

Map of how to get from Buffalo to Cape Girardeau.ExpandLaunch map view
  • Distance: 716 mi
  • Duration: 8h 15m

What companies run services between Buffalo, NY, USA and Cape Girardeau, MO, USA?

You can take a bus from Buffalo to Cape Girardeau via Akron, Cambridge, OH, St Louis Bus Station, and Cape Girardeau in around 21h 14m. Alternatively, United Airlines, Corporate Flight Management Inc, and American Airlines fly from Buffalo Niagara International Airport (BUF) to Cape Girardeau Municipal Airport (CGI) 3 times a day.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers