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How to get fromBuffalo to Carlisleby bus (Greyhound), train (Amtrak), car, plane, train, bus, or bus (Flixbus)

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There are 6 ways to get from Buffalo to Carlisle by bus (Greyhound), train (Amtrak), car, plane, train, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via State College

    best
    1. Take the bus from Buffalo to DuBoisbus bus
    2. Take the bus from DuBois to State Collegebus bus
    3. Take the bus from State College Bus Station to Harrisburg Bus Stationbus bus
    11h 31m
    $98–188

  2. Drive 267.5 mi

    cheapest
    1. Drive from Buffalo to Carlislecar car 267.5 mi
    6h 17m
    $49–71

  3. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Harrisburgtrain train Keystone Service / ...
    14h 30m
    $201–419

  4. Fly, train, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Philadelphia International Airport (PHL)plane plane BUF - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    3. Take the bus from Market Square Transfer Center to Hanover St & High Stbus bus
    7h 59m
    $125–653

  5. Bus

    1. Take the bus from Buffalo to DuBoisbus bus
    2. Take the bus from DuBois to State Collegebus bus
    3. Take the bus from State College Regional Airport to Harrisburg Bus Stationbus bus
    11h 36m
    $105–193

  6. Bus #2

    1. Take the bus from Buffalo to Scranton Bus Stationbus bus Greyhound US0215 / ...
    2. Take the bus from Scranton, Pa to Harrisburg, Pabus bus 771
    11h 41m
    $67–157

Buffalo to Carlisle by bus and foot

Calendar7Weekly Services
Duration11h 31mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Carlisle.ExpandLaunch map view
  • Distance: 352.5 mi
  • Duration: 11h 31m

What companies run services between Buffalo, NY, USA and Carlisle, PA, USA?

You can take a bus from Buffalo to Hanover St & High St via DuBois, State College, State College Bus Station, Harrisburg Bus Station, and Market Square Transfer Center in around 11h 31m. Alternatively, you can take a train from Buffalo to N Hanover St & Louther St WB via Ny Moynihan Train Hall At Penn Station, Harrisburg, and Market Square Transfer Center in around 14h 30m.

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