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How to get fromBuffalo to Charlotte, NCby plane, bus (Greyhound), train (Amtrak), car, or bus

Find Transport to Charlotte, NC

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There are 7 ways to get from Buffalo to Charlotte, NC by plane, bus (Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Charlotte Douglas International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Charlotte Douglas International Airport (CLT)plane plane BUF - CLT
    4h 58m
    $102–561

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Columbusbus bus
    3. Take the bus from Columbus to Charlottebus bus
    19h 54m
    $83–219

  3. Bus via Charleston

    1. Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Charleston, WVbus bus
    3. Take the bus from Charleston, WV to Charlotte Bus Stationbus bus
    16h 24m
    $84–199

  4. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Charlotte Amtrak Stationtrain train Crescent / ...
    22h 56m
    $252–611

  5. Drive  653.6 mi

    1. Drive from Buffalo to Charlotte, NCcar car 653.6 mi
    11h 10m
    $120–173

  6. Bus to Rochester, fly to Charlotte Douglas International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Charlotte Douglas International Airport (CLT)plane plane ROC - CLT
    6h 6m
    $164–850

  7. Bus to Rochester, fly to Concord

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Concord (USA)plane plane ROC - USA
    4h 45m
    $364–1,076

Buffalo to Charlotte, NC by bus and foot

Calendar7Weekly Services
Duration16h 24mAverage Duration
Ticket$84Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Charlotte, NC.ExpandLaunch map view
  • Distance: 569.9 mi
  • Duration: 4h 58m

What companies run services between Buffalo, NY, USA and Charlotte, NC, USA?

American Airlines, Southwest Airlines, and United Airlines fly from Buffalo Niagara International Airport (BUF) to Charlotte Douglas International Airport (CLT) every 2 hours. Alternatively, you can take a bus from Buffalo, NY to Charlotte, NC via Robert K Pfaff Transit Center - Akron, Charleston, WV, Charlotte Bus Station, 4th St & Graham St, and Tuckaseegee Rd & Hazel St in around 16h 24m.

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Need to know: Greyhound

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