There are 6 ways to get from Buffalo to Chicago Loop by plane, subway, train (Amtrak), bus (Greyhound), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Buffalo Niagara International Airport to Chicago Midway International Airport, subway
best- Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane BUF - MDW
- Take the subway from Midway to Washington/Wellssubway
3h 50m$164–317Bus (Greyhound)
cheapest- Take the bus from Buffalo to Cleveland Bus Stationbus Greyhound US0171 / ...
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus Greyhound US0164
11h 52m$85–137Train (Amtrak)
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain Lake Shore Limited
11h 50m$122–442Drive 531.7 mi
- Drive from Buffalo to Chicago Loopcar 531.7 mi
9h 4m$97–141Fly Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane BUF - ORD
4h 2m$174–307Bus to Rochester, fly to Chicago Midway International Airport
- Take the bus from Buffalo to Rochester Bus Stopbus
- Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane ROC - MDW
5h 9m$116–596
Buffalo to Chicago Loop by train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from Buffalo to Chicago Loop is to bus which costs $80 - $140 and takes 11h 52m.
The fastest way to get from Buffalo to Chicago Loop is to fly and subway which takes 3h 50m and costs $160 - $320.
No, there is no direct bus from Buffalo to Chicago Loop. However, there are services departing from Buffalo and arriving at Washington & Lasalle via Cleveland Bus Station and Jefferson & Harrison. The journey, including transfers, takes approximately 11h 52m.
No, there is no direct train from Buffalo to Chicago Loop station. However, there are services departing from Buffalo and arriving at Chicago Union Station via Buffalo Depew Station. The journey, including transfers, takes approximately 11h 50m.
The distance between Buffalo and Chicago Loop is 493 miles. The road distance is 534.8 miles.
The best way to get from Buffalo to Chicago Loop without a car is to train which takes 11h 50m and costs $120 - $450.
It takes approximately 3h 50m to get from Buffalo to Chicago Loop, including transfers.
Buffalo to Chicago Loop bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo to Chicago Loop train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo to Chicago Loop is to train which takes 11h 50m and costs $120 - $450. Alternatively, you can bus, which costs $80 - $140 and takes 11h 52m, you could also fly, which costs $170 - $310 and takes 4h 2m.
What companies run services between Buffalo, NY, USA and Chicago Loop, IL, USA?
Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $120–310 and the journey takes 10h 33m. Alternatively, you can take a bus from Buffalo to Washington & Lasalle via Cleveland Bus Station, Chicago Bus Station, and Jefferson & Harrison in around 11h 52m.
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 39m
- When
- Every day
- Estimated price
- $60–360
Flights from Rochester to Chicago Midway International Airport
- Ave. Duration
- 1h 48m
- When
- Every day
- Estimated price
- $85–550
Flights from Rochester to Chicago Midway International Airport via Baltimore
- Ave. Duration
- 4h 25m
- When
- Tuesday and Wednesday
- Estimated price
- $110–650
- Phone
- +1 888-968-7282
- Website
- Chicago Transit Authority
Subway from Midway to Washington/Wells
- Ave. Duration
- 28 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- Chicago Transit Authority
- Schedules at
- Chicago Transit Authority Schedules & Routes
- Adult
- $2–5
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Buffalo to Cleveland Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- Greyhound
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 25m
- Frequency
- Twice daily
- Estimated price
- $50–85
- Website
- Greyhound
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 20m
- Frequency
- 4 times a day
- Estimated price
- $11–19
- Website
- Greyhound
Want to know more about travelling around United States
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Booking & Getting There
Buffalo to Chicago Loop bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Chicago Loop is 1h behind Buffalo. It is currently 6:46 AM in Buffalo and 5:46 AM in Chicago Loop.
Buffalo to Chicago Loop train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Buffalo to Chicago Loop is 535 miles. It takes approximately 9h 4m to drive from Buffalo to Chicago Loop.
Book your Buffalo to Chicago Loop train tickets online with Omio.
There are 1286+ hotels available in Chicago Loop.