There are 6 ways to get from Buffalo to Chicago Union Station by plane, subway, bus (Greyhound), train (Amtrak), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Buffalo Niagara International Airport to Chicago Midway International Airport, subway
best- Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane BUF - MDW
- Take the subway from Midway to Quincysubway
3h 57m$164–317Bus (Greyhound)
cheapest- Take the bus from Buffalo to Cleveland Bus Stationbus Greyhound US0171 / ...
- Take the bus from Cleveland Bus Station to Chicago Bus Stationbus Greyhound US0164
11h 49m$82–134Train (Amtrak)
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain Lake Shore Limited
11h 50m$132–443Drive 531.3 mi
- Drive from Buffalo to Chicago Union Stationcar 531.3 mi
9h 3m$97–141Fly Buffalo Niagara International Airport to Chicago O'Hare International Airport
- Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane BUF - ORD
4h 17m$174–307Bus to Rochester, fly to Chicago Midway International Airport
- Take the bus from Buffalo to Rochester Bus Stopbus
- Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane ROC - MDW
5h 10m$111–517
Buffalo to Chicago Union Station by bus and foot (Greyhound)
Comparing Your Travel Options
The cheapest way to get from Buffalo to Chicago Union Station is to bus which costs $80 - $140 and takes 11h 49m.
The fastest way to get from Buffalo to Chicago Union Station is to fly and subway which takes 3h 57m and costs $160 - $320.
No, there is no direct bus from Buffalo to Chicago Union Station station. However, there are services departing from Buffalo and arriving at Chicago Bus Station via Cleveland Bus Station. The journey, including transfers, takes approximately 11h 49m.
No, there is no direct train from Buffalo to Chicago Union Station station. However, there are services departing from Buffalo and arriving at Chicago Union Station via Buffalo Depew Station. The journey, including transfers, takes approximately 11h 50m.
The distance between Buffalo and Chicago Union Station is 494 miles. The road distance is 534.4 miles.
The best way to get from Buffalo to Chicago Union Station without a car is to bus which takes 11h 49m and costs $80 - $140.
It takes approximately 3h 57m to get from Buffalo to Chicago Union Station, including transfers.
Buffalo to Chicago Union Station bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo to Chicago Union Station train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo to Chicago Union Station is to bus which takes 11h 49m and costs $80 - $140. Alternatively, you can train, which costs $130 - $450 and takes 11h 50m, you could also fly, which costs $170 - $310 and takes 4h 17m.
What companies run services between Buffalo, NY, USA and Chicago Union Station, IL, USA?
You can take a bus from Buffalo to Chicago Union Station via Cleveland Bus Station and Chicago Bus Station in around 11h 49m. Alternatively, Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $130–310 and the journey takes 10h 33m.
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 38m
- When
- Every day
- Estimated price
- $60–370
Flights from Rochester to Chicago Midway International Airport
- Ave. Duration
- 1h 46m
- When
- Every day
- Estimated price
- $80–470
- Phone
- +1 888-968-7282
- Website
- Chicago Transit Authority
Subway from Midway to Quincy
- Ave. Duration
- 27 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- Chicago Transit Authority
- Schedules at
- Chicago Transit Authority Schedules & Routes
- Adult
- $2–5
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Buffalo to Cleveland Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- Greyhound
Bus from Cleveland Bus Station to Chicago Bus Station
- Ave. Duration
- 7h 25m
- Frequency
- Twice daily
- Estimated price
- $50–85
- Website
- Greyhound
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 20m
- Frequency
- 4 times a day
- Estimated price
- $11–19
- Website
- Greyhound
Want to know more about travelling around United States
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Booking & Getting There
Buffalo to Chicago Union Station bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Chicago Union Station is 1h behind Buffalo. It is currently 3:12 AM in Buffalo and 2:12 AM in Chicago Union Station.
Buffalo to Chicago Union Station train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Buffalo to Chicago Union Station is 534 miles. It takes approximately 9h 3m to drive from Buffalo to Chicago Union Station.
Book your Buffalo to Chicago Union Station train tickets online with Omio.
Book your Buffalo to Chicago Union Station bus tickets online with Omio and FlixBus.
There are 1285+ hotels available in Chicago Union Station.