There are 6 ways to get from Buffalo to Clemson by plane, taxi, bus, train, car, or train (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Greenville–Spartanburg International Airport, taxi
best- Fly from Buffalo Niagara International Airport (BUF) to Greenville–Spartanburg International Airport (GSP)plane BUF - GSP
- Take the taxi from Greenville–Spartanburg International Airport (GSP) to Clemsontaxi
6h 2m$222–802Fly to Asheville Regional Airport, drive
cheapest- Fly from Buffalo Niagara International Airport (BUF) to Asheville Regional Airport (AVL)plane BUF - AVL
- Drive from Asheville-Airport-AVL to Clemsoncar
7h 28m$85–431Bus, taxi
- Take the bus from Buffalo to New York Midtownbus
- Take the bus from New York, NY to Gastonia, NC - Chester St.bus Nyc
- Take the bus from Los Arcos Restaurant - Gastonia to Taqueria Guadalajara - Greenvillebus
- Take the taxi from Taqueria Guadalajara - Greenville to Clemsontaxi
23h 20m$258–375Bus, train
- Take the bus from Buffalo to Newarkbus Adt N813-D / ...
- Take the train from Newark Penn Station to Clemson Amtrak Stationtrain Crescent
24h 12m$225–658Drive 753.8 mi
- Drive from Buffalo to Clemsoncar 753.8 mi
13h 34m$138–199Train (Amtrak)
- Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain Empire Service / ...
- Take the train from Ny Moynihan Train Hall At Penn Station to Clemson Amtrak Stationtrain Crescent
25h 24m$287–683
Buffalo to Clemson by bus and train
Comparing Your Travel Options
The cheapest way to get from Buffalo to Clemson is to drive which costs $130 - $200 and takes 13h 34m.
The fastest way to get from Buffalo to Clemson is to fly and taxi which takes 6h 2m and costs $220 - $800.
No, there is no direct train from Buffalo to Clemson station. However, there are services departing from Buffalo and arriving at Clemson Amtrak Station via Ny Moynihan Train Hall At Penn Station. The journey, including transfers, takes approximately 25h 24m.
The distance between Buffalo and Clemson is 645 miles. The road distance is 758.2 miles.
The best way to get from Buffalo to Clemson without a car is to bus and taxi which takes 23h 20m and costs $250 - $380.
It takes approximately 6h 2m to get from Buffalo to Clemson, including transfers.
Buffalo to Clemson train services, operated by Amtrak, depart from Buffalo station.
Buffalo to Clemson train services, operated by Amtrak, arrive at Ny Moynihan Train Hall At Penn Station.
Yes, the driving distance between Buffalo to Clemson is 758 miles. It takes approximately 13h 34m to drive from Buffalo to Clemson.
Book your Buffalo to Clemson train tickets online with Omio.
What companies run services between Buffalo, NY, USA and Clemson, SC, USA?
You can take a train from Buffalo to Clemson Amtrak Station via Ny Moynihan Train Hall At Penn Station in around 25h 24m.
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Greenville–Spartanburg International Airport via Reagan Washington
- Ave. Duration
- 6h 4m
- When
- Every day
- Estimated price
- $110–650
Flights from Buffalo Niagara International Airport to Greenville–Spartanburg International Airport via Philadelphia
- Ave. Duration
- 5h 54m
- When
- Every day
- Estimated price
- $120–700
Flights from Buffalo Niagara International Airport to Greenville–Spartanburg International Airport via Charlotte
- Ave. Duration
- 5h 39m
- When
- Every day
- Estimated price
- $110–650
Flights from Buffalo Niagara International Airport to Asheville Regional Airport via Reagan Washington
- Ave. Duration
- 5h 49m
- When
- Every day
- Estimated price
- $75–410
Flights from Buffalo Niagara International Airport to Asheville Regional Airport via Philadelphia
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $80–440
Flights from Buffalo Niagara International Airport to Asheville Regional Airport via Charlotte
- Ave. Duration
- 6h 44m
- When
- Every day
- Estimated price
- $70–410
Flights from Buffalo Niagara International Airport to Asheville Regional Airport via New York La Guardia
- Ave. Duration
- 9h 4m
- When
- Every day
- Estimated price
- $85–460
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Newark Penn Station to Clemson Amtrak Station
- Ave. Duration
- 15h 47m
- Frequency
- Once daily
- Estimated price
- $170–420
- Website
- Amtrak
Train from Buffalo to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 8h 17m
- Frequency
- 3 times a day
- Estimated price
- $100–260
- Website
- Amtrak
Train from Ny Moynihan Train Hall At Penn Station to Clemson Amtrak Station
- Ave. Duration
- 16h 7m
- Frequency
- Once daily
- Estimated price
- $180–430
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Buffalo to New York Midtown
- Ave. Duration
- 8h 35m
- Frequency
- Every 4 hours
- Estimated price
- $65–110
- Schedules at
- Flixbus USA
- Ave. Duration
- 46 min
- Estimated price
- $80–150
GVL Taxi
- Phone
- +1 864-920-3352
- Website
- gvltaxi.com
Personal Touch Transportation
- Phone
- +18645250420
Yellow Cab Greenville
- Phone
- +1 864-233-6666
- Website
- yellowcabgreenville.com
Checker Cab
- Phone
- +1 864-583-2721
GVL Taxi
- Phone
- +1 864-920-3352
- Website
- gvltaxi.com
Personal Touch Transportation
- Phone
- +18645250420
Yellow Cab Greenville
- Phone
- +1 864-233-6666
- Website
- yellowcabgreenville.com
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Booking & Getting There
There are 126+ hotels available in Clemson.






