There are 5 ways to get from Buffalo to Cleveland Clinic by bus (Greyhound), train (Amtrak), car, plane, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus (Greyhound)
best- Take the bus from Buffalo to Cleveland Bus Stationbus Greyhound US0171 / ...
5h 31m$41–69Bus via Akron
cheapest- Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus Buffalo
- Take the bus from Robert K Pfaff Transit Center - Akron to Euclid Ave & E. 100th St @ Cleveland Clbus 61
6h 20m$24–63Train (Amtrak)
- Take the train from Buffalo Depew Station to Cleveland Amtraktrain Lake Shore Limited
5h 32m$65–268Drive 184.5 mi
- Drive from Buffalo to Cleveland Cliniccar 184.5 mi
3h 25m$34–49Fly
- Fly from Buffalo Niagara International Airport (BUF) to Cleveland-Hopkins International Airport (CLE)plane BUF - CLE
5h 25m$104–631
Buffalo to Cleveland Clinic by bus, foot, and subway (Greyhound)
Questions & Answers
The cheapest way to get from Buffalo to Cleveland Clinic is to drive which costs $30 - $50 and takes 3h 25m.
The fastest way to get from Buffalo to Cleveland Clinic is to drive which takes 3h 25m and costs $30 - $50.
No, there is no direct bus from Buffalo to Cleveland Clinic. However, there are services departing from Buffalo and arriving at Cedar Av & E 93Rd St via West Park Station Stop #4 and West Roadway & Superior Av. The journey, including transfers, takes approximately 5h 31m.
No, there is no direct train from Buffalo to Cleveland Clinic station. However, there are services departing from Buffalo and arriving at E 105Th St-Quincy Av Station via Buffalo Depew Station and Tower City Station Track 13. The journey, including transfers, takes approximately 5h 32m.
The distance between Buffalo and Cleveland Clinic is 217 miles. The road distance is 185.6 miles.
The best way to get from Buffalo to Cleveland Clinic without a car is to bus which takes 5h 31m and costs $40 - $70.
It takes approximately 5h 31m to get from Buffalo to Cleveland Clinic, including transfers.
Buffalo to Cleveland Clinic bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo to Cleveland Clinic train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo to Cleveland Clinic is to bus which takes 5h 31m and costs $40 - $70. Alternatively, you can train, which costs $65 - $270 and takes 5h 32m, you could also fly, which costs $100 - $650 and takes 5h 25m.
What companies run services between Buffalo, NY, USA and Cleveland Clinic, OH, USA?
Greyhound USA operates a bus from Buffalo to Cleveland Bus Station twice daily. Tickets cost $30–60 and the journey takes 3h 15m. Alternatively, Amtrak operates a train from Buffalo Depew Station to Cleveland Amtrak twice daily. Tickets cost $60–130 and the journey takes 3h 14m.
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Cleveland-Hopkins International Airport via Detroit
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- $95–600
Flights from Buffalo Niagara International Airport to Cleveland-Hopkins International Airport via New York La Guardia
- Ave. Duration
- 4h 42m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–750
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Cleveland-Hopkins International Airport via Reagan Washington
- Ave. Duration
- 4h 5m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–750
Flights from Buffalo Niagara International Airport to Cleveland-Hopkins International Airport via Philadelphia
- Ave. Duration
- 5h 6m
- When
- Every day
- Estimated price
- $140–750
Flights from Buffalo Niagara International Airport to Cleveland-Hopkins International Airport via New York La Guardia
- Ave. Duration
- 4h 52m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–750
- Website
- united.com
Flights from Buffalo Niagara International Airport to Cleveland-Hopkins International Airport via Washington Dulles
- Ave. Duration
- 3h 47m
- When
- Every day
- Estimated price
- $130–700
Flights from Buffalo Niagara International Airport to Cleveland-Hopkins International Airport via Newark
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $140–750
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Cleveland-Hopkins International Airport via Baltimore
- Ave. Duration
- 4h 45m
- When
- Sunday, Tuesday, Wednesday, and Saturday
- Estimated price
- $130–700
Flights from Buffalo Niagara International Airport to Cleveland-Hopkins International Airport via Chicago Midway
- Ave. Duration
- 5h 37m
- When
- Sunday, Tuesday, and Wednesday
- Estimated price
- $150–800
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Buffalo Depew Station to Cleveland Amtrak
- Ave. Duration
- 3h 14m
- Frequency
- Twice daily
- Estimated price
- $60–130
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Buffalo to Cleveland Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $30–60
- Website
- https://www.greyhound.com/
- Phone
- +1 888-378-3823
- [email protected]
- Website
- baronsbus.com
Bus from Buffalo, NY to Robert K Pfaff Transit Center - Akron
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Estimated price
- $22–65
- Website
- https://baronsbus.com
- Phone
- +1 330 762 0341
- Website
- akronmetro.org
Bus from Robert K Pfaff Transit Center - Akron to Euclid Ave & E. 100th St @ Cleveland Cl
- Ave. Duration
- 1h 22m
- Frequency
- 4 times a day
- Estimated price
- $2
- Schedules at
- akronmetro.org
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More Questions & Answers
Buffalo to Cleveland Clinic bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Buffalo to Cleveland Clinic train services, operated by Amtrak, arrive at Cleveland Amtrak station.
Yes, the driving distance between Buffalo to Cleveland Clinic is 186 miles. It takes approximately 3h 25m to drive from Buffalo to Cleveland Clinic.
There are 632+ hotels available in Cleveland Clinic.