Rome2Rio

How to get fromBuffalo to Des Moinesby plane, bus (Greyhound), train, bus, or car

Find Transport to Des Moines

See all options

There are 7 ways to get from Buffalo to Des Moines by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM)plane plane BUF - DSM
    5h 11m
    $203–999

  2. Bus via Akron

    cheapest
    1. Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Cleveland, OHbus bus
    3. Take the bus from Cleveland to Chicagobus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    21h 45m
    $110–281

  3. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    19h 10m
    $131–258

  4. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    19h 29m
    $222–585

  5. Drive 846.5 mi

    1. Drive from Buffalo to Des Moinescar car 846.5 mi
    14h 17m
    $155–224

  6. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Des Moines (DSM)plane plane ROC - DSM
    6h 51m
    $217–966

  7. Train, bus via Galesburg

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    21h 21m
    $252–655

Buffalo to Des Moines by bus (Greyhound)

Calendar14Weekly Buses
Duration19h 10mAverage Duration
Ticket$131Cheapest Price
See schedules

Questions & Answers

Map of how to get from Buffalo to Des Moines.ExpandLaunch map view
  • Distance: 785.3 mi
  • Duration: 5h 11m

What companies run services between Buffalo, NY, USA and Des Moines, IA, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Buffalo to Des Moines via Cleveland Bus Station and Chicago Bus Station in around 19h 10m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers