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How to get fromBuffalo to Florenceby plane, bus (Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

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There are 6 ways to get from Buffalo to Florence by plane, bus (Flixbus), train (Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Florence Regional Airport (FLO)plane plane BUF - FLO
    5h 56m
    $87–425

  2. Bus

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus 2686 / ...
    2. Take the bus from New York, NY to Florence, SCbus bus Nyc
    21h 59m
    $154–230

  3. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    23h 58m
    $582–922

  4. Drive  723.9 mi

    1. Drive from Buffalo to Florencecar car 723.9 mi
    14h 49m
    $133–191

  5. Fly to Myrtle Beach, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR)plane plane BUF - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    7h 57m
    $90–414

  6. Bus via Raleigh

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus
    2. Take the bus from Port Authority Bus Terminal to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    22h 40m
    $173–428

Buffalo to Florence by train (Amtrak)

Calendar14Weekly Trains
Duration23h 58mAverage Duration
Ticket$582Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Florence.ExpandLaunch map view
  • Distance: 621 mi
  • Duration: 5h 56m

What companies run services between Buffalo, NY, USA and Florence, SC, USA?

American Airlines flies from Buffalo Niagara International Airport (BUF) to Florence Regional Airport (FLO) 5 times a day. Alternatively, you can take a bus from Buffalo to Florence, SC via New York Midtown, 23 St, East Broadway, and New York, NY in around 21h 59m.

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Want to know more about travelling around United States

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