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How to get fromBuffalo to Florenceby plane, bus (Flixbus, Greyhound), train (Amtrak), car, bus, or bus (Greyhound)

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There are 6 ways to get from Buffalo to Florence by plane, bus (Flixbus, Greyhound), train (Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Florence Regional Airport (FLO)plane plane BUF - FLO
    5h 39m
    $82–425

  2. Bus via Fayetteville

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Florence Bus Stationbus bus
    21h 40m
    $166–264

  3. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    23h 58m
    $582–921

  4. Drive  723.9 mi

    1. Drive from Buffalo to Florencecar car 723.9 mi
    14h 49m
    $128–185

  5. Fly to Myrtle Beach, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR)plane plane BUF - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 22m
    $90–415

  6. Bus

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus Greyhound US0205 / ...
    2. Take the bus from New York, NY to Florence, SCbus bus Nyc
    21h 40m
    $145–381

Buffalo to Florence by bus

Calendar4Weekly Buses
Duration21h 40mAverage Duration
Ticket$166Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Florence.ExpandLaunch map view
  • Distance: 621 mi
  • Duration: 5h 39m

What companies run services between Buffalo, NY, USA and Florence, SC, USA?

American Airlines flies from Buffalo Niagara International Airport (BUF) to Florence Regional Airport (FLO) 3 times a day. Alternatively, you can take a bus from Buffalo to Florence Bus Station via Newark Penn Station and Fayetteville Bus Station in around 21h 40m.

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