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How to get fromBuffalo to Florida Keysby plane, bus, train, car, shuttle, or ferry

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There are 9 ways to get from Buffalo to Florida Keys by plane, bus, train, car, shuttle, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Key West International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW)plane plane BUF - EYW
    9h 24m
    $169–546

  2. Bus, train via Newark

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the train from Newark Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    43h 14m
    $431–962

  3. Drive  1,521.1 mi

    1. Drive from Buffalo to Florida Keyscar car 1,521.1 mi
    26h 10m
    $278–401

  4. Fly Buffalo Niagara International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Buffalo Niagara International Airport (BUF) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane BUF - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 31m
    $324–696

  5. Bus to Rochester, fly to Key West International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Key West International Airport (EYW)plane plane ROC - EYW
    11h 23m
    $236–785

  6. Bus to Toronto Pearson International Airport, fly to Key West International Airport

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Key West International Airport (EYW)plane plane YYZ - EYW
    13h 5m
    $182–533

  7. Fly Buffalo Niagara International Airport to Ft. Myers, ferry

    1. Fly from Buffalo Niagara International Airport (BUF) to Ft. Myers (RSW)plane plane BUF - RSW
    2. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    13h 7m
    $288–782

  8. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    44h 4m
    $478–1,116

  9. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    2d 3h
    $472–1,226

Buffalo to Florida Keys by bus, train, taxi, and foot

Calendar7Weekly Services
Duration43h 14mAverage Duration
Ticket$431Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Florida Keys.ExpandLaunch map view
  • Distance: 1,315.1 mi
  • Duration: 9h 24m

What companies run services between Buffalo, NY, USA and Florida Keys, FL, USA?

Delta, American Airlines, and three other airlines fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW) every 4 hours.

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Ferry operators

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