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How to get fromBuffalo to Great Lakesby plane, train, train (Amtrak), bus (Greyhound), car, or bus

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There are 6 ways to get from Buffalo to Great Lakes by plane, train, train (Amtrak), bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Chicago Midway International Airport, train

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    2. Take the train from Chicago OTC to Great Lakestrain train
    5h 25m
    $173–410

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    15h 16m
    $88–169

  3. Train

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago OTC to Great Lakestrain train Up-N
    13h 44m
    $170–495

  4. Drive 566.2 mi

    1. Drive from Buffalo to Great Lakescar car 566.2 mi
    9h 48m
    $104–150

  5. Fly Buffalo Niagara International Airport to Chicago O'Hare International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    2. Take the train from Clybourn to Great Lakestrain train
    5h 42m
    $183–340

  6. Bus to Rochester, fly to Chicago O'Hare International Airport, train

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    3. Take the train from Clybourn to Great Lakestrain train
    7h 24m
    $101–436

Buffalo to Great Lakes by train, foot, and bus

Calendar14Weekly Services
Duration13h 44mAverage Duration
Ticket$170Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Great Lakes.ExpandLaunch map view
  • Distance: 521.2 mi
  • Duration: 5h 25m

What companies run services between Buffalo, NY, USA and Great Lakes, IL, USA?

You can take a train from Buffalo to Great Lakes via Buffalo Depew Station, Chicago Union Station, Washington & Jefferson, Washington & Canal, and Chicago OTC in around 13h 44m. Alternatively, you can take a bus from Buffalo to Great Lakes via Cleveland Bus Station, Chicago Bus Station, Union Station Transit Center, Michigan & Hubbard, Rogers & Paulina, Howard CTA Station, Highland Park Metra Station, and Highland Park in around 15h 16m.

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