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How to get fromBuffalo to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

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There are 10 ways to get from Buffalo to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Mcghee Tyson Airport, drive

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 50m
    $186–994

  2. Fly Buffalo Niagara International Airport to Hartsfield-Jackson Atlanta International Airport, drive

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane BUF - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    7h 25m
    $91–363

  3. Bus, drive

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus
    2. Take the bus from New York to Knoxvillebus bus Nyc
    3. Drive from Knoxville to Great Smoky Mountainscar car
    23h 31m
    $168–411

  4. Train, bus, drive via Greensboro

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    26h
    $342–700

  5. Drive 723.2 mi

    1. Drive from Buffalo to Great Smoky Mountainscar car 723.2 mi
    12h 54m
    $132–191

  6. Fly Buffalo Niagara International Airport to Asheville Regional Airport, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Asheville Regional Airport (AVL)plane plane BUF - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    7h 20m
    $115–550

  7. Bus to Rochester, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Mcghee Tyson Airport (TYS)plane plane ROC - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    8h 21m
    $210–1,011

  8. Train, bus, drive

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    23h 43m
    $253–421

  9. Bus, drive via Farragut

    1. Take the bus from Buffalo to New York Midtownbus bus
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    24h 4m
    $186–257

  10. Train, bus, drive #2

    1. Take the train from Buffalo to New York Penn Stationtrain train
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    3. Drive from Knoxville, TN to Great Smoky Mountainscar car
    24h 25m
    $229–415

Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) flights

Calendar90Weekly Planes
Duration4h 50mAverage Duration
Ticket$178Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 636.4 mi
  • Duration: 6h 50m

What companies run services between Buffalo, NY, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Buffalo to Great Smoky Mountains. However, you can take the bus to Buffalo Niagara International Airport, walk to Buffalo Niagara International Airport (BUF) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Buffalo to Great Smoky Mountains via Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 23h 31m.

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