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How to get fromBuffalo to Greenvilleby plane, bus (Flixbus), train, bus, car, taxi, or bus (Greyhound)

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There are 6 ways to get from Buffalo to Greenville by plane, bus (Flixbus), train, bus, car, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Greenville–Spartanburg International Airport (GSP)plane plane BUF - GSP
    5h 17m
    $181–823

  2. Drive 730.7 mi

    cheapest
    1. Drive from Buffalo to Greenvillecar car 730.7 mi
    12h 59m
    $134–193

  3. Bus via New York

    1. Take the bus from Buffalo to New York Midtownbus bus
    2. Take the bus from New York, NY to Gastonia, NC - Chester St.bus bus Nyc
    3. Take the bus from Los Arcos Restaurant - Gastonia to Taqueria Guadalajara - Greenvillebus bus
    22h 53m
    $221–414

  4. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Charlotte Amtrak Stationtrain train
    3. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    25h 51m
    $388–851

  5. Fly to Asheville Regional Airport, taxi

    1. Fly from Buffalo Niagara International Airport (BUF) to Asheville Regional Airport (AVL)plane plane BUF - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    6h 16m
    $241–698

  6. Bus

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    30h
    $213–460

Buffalo Niagara International Airport (BUF) to Greenville–Spartanburg International Airport (GSP) flights

Calendar98Weekly Planes
Duration4h 43mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Greenville.ExpandLaunch map view
  • Distance: 609.1 mi
  • Duration: 5h 17m

What companies run services between Buffalo, NY, USA and Greenville, SC, USA?

United Airlines, American Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from Buffalo to Greenville via New York Midtown, New York City Chinatown, New York, NY, Gastonia, NC - Chester St., Los Arcos Restaurant - Gastonia, and Taqueria Guadalajara - Greenville in around 22h 53m.

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