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How to get fromBuffalo to Hartsvilleby plane, taxi, bus, train (Amtrak), car, bus (Flixbus), or train

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There are 7 ways to get from Buffalo to Hartsville by plane, taxi, bus, train (Amtrak), car, bus (Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport, taxi

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Florence Regional Airport (FLO)plane plane BUF - FLO
    2. Take the taxi from Florence Regional Airport (FLO) to Hartsvilletaxi taxi
    8h 7m
    $157–522

  2. Drive  734.2 mi

    cheapest
    1. Drive from Buffalo to Hartsvillecar car 734.2 mi
    13h 1m
    $134–194

  3. Bus, taxi

    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Charlestonbus bus
    3. Take the bus from Charleston, WV to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Camdenbus bus
    5. Take the taxi from Camden to Hartsvilletaxi taxi
    19h 2m
    $215–366

  4. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train Palmetto / ...
    24h 33m
    $350–712

  5. Fly to Charlotte Douglas International Airport, bus, taxi

    1. Fly from Buffalo Niagara International Airport (BUF) to Charlotte Douglas International Airport (CLT)plane plane BUF - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the taxi from Camden to Hartsvilletaxi taxi
    7h 40m
    $233–778

  6. Bus

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus N2686 / ...
    2. Take the bus from New York, NY to Florence, SCbus bus Nyc
    22h 39m
    $223–317

  7. Bus, train, taxi

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Camden Stationtrain train
    3. Take the taxi from Camden Station to Hartsvilletaxi taxi
    27h 36m
    $371–813

Buffalo Niagara International Airport (BUF) to Florence Regional Airport (FLO) flights

Calendar28Weekly Planes
Duration7h 26mAverage Duration
Ticket$77Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Hartsville.ExpandLaunch map view
  • Distance: 644.3 mi
  • Duration: 8h 7m

What companies run services between Buffalo, NY, USA and Hartsville, SC, USA?

You can take a train from Buffalo to Hartsville via Ny Moynihan Train Hall At Penn Station and Florence Station in around 24h 33m. Alternatively, you can take a bus from Buffalo to Hartsville via New York Midtown, 23 St, East Broadway, New York, NY, and Florence, SC in around 22h 39m.

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