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How to get fromBuffalo to Jefferson Cityby plane, train (Amtrak), bus (Greyhound), car, bus, shuttle, or train

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There are 7 ways to get from Buffalo to Jefferson City by plane, train (Amtrak), bus (Greyhound), car, bus, shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Columbia Regional Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Columbia Regional Airport (COU)plane plane BUF - COU
    6h 35m
    $202–738

  2. Drive 858.7 mi

    cheapest
    1. Drive from Buffalo to Jefferson Citycar car 858.7 mi
    14h 48m
    $157–227

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Jefferson City Stationtrain train Lincoln Service Missouri River Runner
    20h 36m
    $302–755

  4. Bus

    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Cambridgebus bus
    3. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Jefferson Citybus bus
    23h 13m
    $252–368

  5. Bus to Rochester, fly to Columbia Regional Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Columbia Regional Airport (COU)plane plane ROC - COU
    7h 45m
    $230–705

  6. Fly Buffalo Niagara International Airport to Lambert–St. Louis International Airport, shuttle

    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    2. Take a shuttle bus from St Louis International Airport to Jefferson City, Missourishuttle bus
    7h 50m
    $287–978

  7. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus
    3. Take the train from St. Louis to Jefferson City Stationtrain train
    24h 50m
    $216–483

Buffalo to Jefferson City by train (Amtrak)

Calendar7Weekly Trains
Duration20h 36mAverage Duration
Ticket$302Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Jefferson City.ExpandLaunch map view
  • Distance: 791.9 mi
  • Duration: 6h 35m

What companies run services between Buffalo, NY, USA and Jefferson City, MO, USA?

United Airlines and American Airlines fly from Buffalo Niagara International Airport (BUF) to Columbia Regional Airport (COU) every 3 hours. Alternatively, you can take a train from Buffalo to Jefferson City Station via Buffalo Depew Station and Chicago Union Station in around 20h 36m.

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