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How to get fromBuffalo to Jeffersonvilleby plane, car, bus (Flixbus, Greyhound, Amtrak), train, bus, or bus (Greyhound, Amtrak)

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There are 10 ways to get from Buffalo to Jeffersonville by plane, car, bus (Flixbus, Greyhound, Amtrak), train, bus, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Blue Grass Airport, drive

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Blue Grass Airport (LEX)plane plane BUF - LEX
    2. Drive from Lexington-Airport-LEX to Jeffersonvillecar car
    6h 24m
    $80–411

  2. Bus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    15h 40m
    $105–176

  3. Train, bus (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    21h 31m
    $415–801

  4. Drive  531.1 mi

    1. Drive from Buffalo to Jeffersonvillecar car 531.1 mi
    9h 2m
    $97–140

  5. Fly Buffalo Niagara International Airport to Covington, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Covington (CVG)plane plane BUF - CVG
    2. Drive from Covington (CVG) to Jeffersonvillecar car
    6h 29m
    $169–267

  6. Fly Buffalo Niagara International Airport to Louisville International Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    7h 38m
    $114–708

  7. Bus to Toronto Pearson International Airport, fly to Covington, drive

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Covington (CVG)plane plane YYZ - CVG
    3. Drive from Covington (CVG) to Jeffersonvillecar car
    8h 20m
    $124–584

  8. Train, bus via Toledo

    1. Take the train from Buffalo Depew Station to Toledotrain train
    2. Take the bus from Toledo to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    16h 11m
    $206–496

  9. Bus via Court @ Meigs

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    16h 25m
    $88–178

  10. Train, bus via Toledo #2

    1. Take the train from Buffalo Depew Station to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    18h 5m
    $222–362

Buffalo to Jeffersonville by bus and foot

Calendar7Weekly Services
Duration15h 40mAverage Duration
Ticket$105Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Jeffersonville.ExpandLaunch map view
  • Distance: 541.5 mi
  • Duration: 6h 24m

What companies run services between Buffalo, NY, USA and Jeffersonville, IN, USA?

You can take a bus from Buffalo to Court @ Spring via Columbus, E Main St & S 5Th St, S Grant Ave & E Mound St, Columbus, Indianapolis Union Station, Louisville, KY, and Liberty @ Roy Wilkins in around 15h 40m. Alternatively, Delta, Southwest Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF) hourly.

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