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How to get fromBuffalo to Knoxvilleby plane, bus (Greyhound), car, bus, train, or bus (Flixbus)

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There are 8 ways to get from Buffalo to Knoxville by plane, bus (Greyhound), car, bus, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Mcghee Tyson Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    5h 44m
    $217–972

  2. Fly Buffalo Niagara International Airport to Nashville, drive

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Nashville (BNA)plane plane BUF - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 15m
    $117–522

  3. Bus

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus Greyhound US0205 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    21h 42m
    $240–501

  4. Drive  682.8 mi

    1. Drive from Buffalo to Knoxvillecar car 682.8 mi
    11h 30m
    $125–180

  5. Bus to Rochester, fly to Mcghee Tyson Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Mcghee Tyson Airport (TYS)plane plane ROC - TYS
    6h 46m
    $264–1,116

  6. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    21h 54m
    $255–421

  7. Bus via New York

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus N2686 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    22h 11m
    $252–362

  8. Train, bus via Farragut

    1. Take the train from Buffalo to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    22h 32m
    $301–533

Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) flights

Calendar109Weekly Planes
Duration4h 45mAverage Duration
Ticket$167Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Knoxville.ExpandLaunch map view
  • Distance: 591.8 mi
  • Duration: 5h 44m

What companies run services between Buffalo, NY, USA and Knoxville, TN, USA?

United Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Buffalo to Knoxville via Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 21h 42m.

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