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How to get fromBuffalo to Knoxvilleby plane, bus, car, train, or bus (Flixbus)

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There are 8 ways to get from Buffalo to Knoxville by plane, bus, car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Mcghee Tyson Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    5h 29m
    $221–998

  2. Fly Buffalo Niagara International Airport to Nashville, drive

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Nashville (BNA)plane plane BUF - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 59m
    $121–538

  3. Bus

    1. Take the bus from Buffalo to New Yorkbus bus Adt N813 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    21h 26m
    $245–526

  4. Drive 682.8 mi

    1. Drive from Buffalo to Knoxvillecar car 682.8 mi
    11h 30m
    $125–180

  5. Bus to Rochester, fly to Mcghee Tyson Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Mcghee Tyson Airport (TYS)plane plane ROC - TYS
    6h 46m
    $263–1,113

  6. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    21h 54m
    $257–423

  7. Bus via New York

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus N2686 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    22h 8m
    $248–356

  8. Train, bus via Farragut

    1. Take the train from Buffalo to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    22h 32m
    $302–536

Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) flights

Calendar107Weekly Planes
Duration4h 45mAverage Duration
Ticket$162Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Knoxville.ExpandLaunch map view
  • Distance: 590 mi
  • Duration: 5h 29m

What companies run services between Buffalo, NY, USA and Knoxville, TN, USA?

Delta, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Buffalo to Knoxville via New York, 42 St-Times Square, Canal St, New York, and Knoxville in around 21h 26m.

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