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How to get fromBuffalo to La Crosseby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)

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There are 6 ways to get from Buffalo to La Crosse by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to La Crosse (LSE)plane plane BUF - LSE
    6h 38m
    $121–601

  2. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    17h 49m
    $262–675

  3. Bus via Chicago

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to La Crossebus bus
    19h 27m
    $151–300

  4. Drive 812.3 mi

    1. Drive from Buffalo to La Crossecar car 812.3 mi
    13h 43m
    $149–215

  5. Fly to Minneapolis–Saint Paul International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Minneapolis–Saint Paul International Airport (MSP)plane plane BUF - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    7h 48m
    $174–816

  6. Bus

    1. Take the bus from Buffalo to Toronto Pearson Airportbus bus
    2. Take the bus from Toronto Pearson Airport to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Appleton Transit Centerbus bus
    4. Take the bus from Appleton Valley Transit to La Crosse Grand River Stationbus bus
    27h 5m
    $186–281

Buffalo to La Crosse by train (Amtrak)

Calendar14Weekly Trains
Duration17h 49mAverage Duration
Ticket$262Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to La Crosse.ExpandLaunch map view
  • Distance: 649.9 mi
  • Duration: 6h 38m

What companies run services between Buffalo, NY, USA and La Crosse, WI, USA?

American Airlines flies from Buffalo Niagara International Airport (BUF) to La Crosse (LSE) every 4 hours. Alternatively, you can take a train from Buffalo to La Crosse Amtrak Station via Buffalo Depew Station and Chicago Union Station in around 17h 49m.

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