Rome2Rio

How to get fromBuffalo to Lake Cityby plane, bus, bus (Flixbus, Greyhound), train, or car

Find Transport to Lake City

See all options

There are 9 ways to get from Buffalo to Lake City by plane, bus, bus (Flixbus, Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Jacksonville, bus

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Jacksonville (JAX)plane plane BUF - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    9h 24m
    $114–572

  2. Bus

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    28h 40m
    $226–357

  3. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    31h 10m
    $755–1,242

  4. Drive  1,086.7 mi

    1. Drive from Buffalo to Lake Citycar car 1,086.7 mi
    18h 31m
    $192–278

  5. Fly Buffalo Niagara International Airport to Orlando, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Orlando (MCO)plane plane BUF - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    10h 31m
    $215–431

  6. Fly Buffalo Niagara International Airport to Gainesville Regional Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Gainesville Regional Airport (GNV)plane plane BUF - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    11h 1m
    $133–428

  7. Fly Buffalo Niagara International Airport to Valdosta, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Valdosta (VLD)plane plane BUF - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    11h 6m
    $160–459

  8. Bus to Toronto Pearson International Airport, fly to Jacksonville, bus

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Jacksonville (JAX)plane plane YYZ - JAX
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    11h 30m
    $123–529

  9. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    36h 36m
    $663–1,183

Buffalo to Lake City by bus

Calendar4Weekly Buses
Duration28h 40mAverage Duration
Ticket$226Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Buffalo to Lake City.ExpandLaunch map view
  • Distance: 965.3 mi
  • Duration: 9h 24m

What companies run services between Buffalo, NY, USA and Lake City, FL, USA?

You can take a bus from Buffalo to Lake City Bus Station via Newark Penn Station and Jacksonville in around 28h 40m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There