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How to get fromBuffalo to Lexingtonby plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

Find Transport to Lexington

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There are 7 ways to get from Buffalo to Lexington by plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Columbia (CAE)plane plane BUF - CAE
    5h 32m
    $100–447

  2. Bus via Columbus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to Charlottebus bus
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Columbia, SCbus bus Nyc
    22h 30m
    $180–300

  3. Train, bus via Charlotte

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Charlotte Amtrak Stationtrain train
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Columbia, SCbus bus Nyc
    26h 21m
    $654–1,037

  4. Drive  754.4 mi

    1. Drive from Buffalo to Lexingtoncar car 754.4 mi
    12h 59m
    $138–199

  5. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the bus from New York, NY to Columbia, SCbus bus Nyc
    24h 22m
    $371–556

  6. Bus

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus 2686 / ...
    2. Take the bus from New York, NY to Columbia, SCbus bus Nyc
    24h 34m
    $191–277

  7. Train, bus #2

    1. Take the train from Buffalo to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York, NY to Columbia, SCbus bus Nyc
    25h 5m
    $245–461

Buffalo Niagara International Airport (BUF) to Columbia (CAE) flights

Calendar118Weekly Planes
Duration5h 20mAverage Duration
Ticket$72Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Lexington.ExpandLaunch map view
  • Distance: 655.1 mi
  • Duration: 5h 32m

What companies run services between Buffalo, NY, USA and Lexington, SC, USA?

United Airlines, American Airlines, and Delta fly from Buffalo Niagara International Airport (BUF) to Columbia (CAE) hourly. Alternatively, you can take a bus from Buffalo to Lexington via Columbus, Charlotte Bus Station, Camden, and Columbia, SC in around 22h 30m.

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