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How to get fromBuffalo to Lexingtonby plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

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There are 7 ways to get from Buffalo to Lexington by plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Columbia (CAE)plane plane BUF - CAE
    5h 11m
    $270–1,363

  2. Drive 754.4 mi

    cheapest
    1. Drive from Buffalo to Lexingtoncar car 754.4 mi
    12h 59m
    $138–199

  3. Bus via Columbus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus - Mound St to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Columbia, SCbus bus Nyc
    22h 30m
    $175–324

  4. Train, bus via Charlotte

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Charlotte Amtrak Stationtrain train
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Columbia, SCbus bus Nyc
    26h 21m
    $414–804

  5. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the bus from New York, NY to Columbia, SCbus bus Nyc
    24h 22m
    $271–469

  6. Bus

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus 2686 / ...
    2. Take the bus from New York, NY to Columbia, SCbus bus Nyc
    24h 34m
    $203–304

  7. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Raleigh Union Stationtrain train
    3. Take the bus from S Saunders St at Chapanoke Rd - Raleigh to Columbia, SCbus bus Nyc
    28h 49m
    $313–705

Buffalo Niagara International Airport (BUF) to Columbia (CAE) flights

Calendar137Weekly Planes
Duration5h 9mAverage Duration
Ticket$241Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Lexington.ExpandLaunch map view
  • Distance: 653.3 mi
  • Duration: 5h 11m

What companies run services between Buffalo, NY, USA and Lexington, SC, USA?

United Airlines, American Airlines, and Delta fly from Buffalo Niagara International Airport (BUF) to Columbia (CAE) hourly. Alternatively, you can take a bus from Buffalo to Lexington via Columbus, Columbus - Mound St, Charlotte Bus Station, Camden, and Columbia, SC in around 22h 30m.

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Train operators
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