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How to get fromBuffalo to Louisvilleby plane, bus, car, or bus (Greyhound)

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There are 6 ways to get from Buffalo to Louisville by plane, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Louisville International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    6h 11m
    $127–731

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Cincinnati, OHbus bus Buffalo
    2. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus Cleveland
    12h 45m
    $55–140

  3. Drive 530.9 mi

    1. Drive from Buffalo to Louisvillecar car 530.9 mi
    9h
    $97–140

  4. Fly Buffalo Niagara International Airport to Blue Grass Airport, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Blue Grass Airport (LEX)plane plane BUF - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 13m
    $199–1,047

  5. Bus to Rochester, fly to Louisville International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Louisville International Airport (SDF)plane plane ROC - SDF
    7h 30m
    $401–648

  6. Bus via Brook Park

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Cincinnati Bus Stationbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    13h 45m
    $81–178

Buffalo to Louisville by bus

Calendar7Weekly Buses
Duration12h 45mAverage Duration
Ticket$55Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Louisville.ExpandLaunch map view
  • Distance: 509.4 mi
  • Duration: 6h 11m

What companies run services between Buffalo, NY, USA and Louisville, KY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a bus from Buffalo, NY to Louisville, KY Bus Station via Cincinnati, OH and Greyhound Station Cincinnati in around 12h 45m.

Airlines
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