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How to get fromBuffalo to Louisvilleby plane, bus (Flixbus, Greyhound, Amtrak), train, bus, car, or bus (Greyhound, Amtrak)

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There are 9 ways to get from Buffalo to Louisville by plane, bus (Flixbus, Greyhound, Amtrak), train, bus, car, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Louisville International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF)plane plane BUF - SDF
    6h 26m
    $123–705

  2. Fly Buffalo Niagara International Airport to Blue Grass Airport, drive

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Blue Grass Airport (LEX)plane plane BUF - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 23m
    $80–411

  3. Bus via Columbus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    14h 47m
    $105–174

  4. Train, bus (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    20h 39m
    $414–799

  5. Drive  530.9 mi

    1. Drive from Buffalo to Louisvillecar car 530.9 mi
    9h 1m
    $97–140

  6. Bus to Rochester, fly to Louisville International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Louisville International Airport (SDF)plane plane ROC - SDF
    7h 40m
    $201–1,046

  7. Train, bus via Toledo

    1. Take the train from Buffalo Depew Station to Toledotrain train
    2. Take the bus from Toledo to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    14h 51m
    $205–494

  8. Bus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    15h 5m
    $87–175

  9. Train, bus via Toledo #2

    1. Take the train from Buffalo Depew Station to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    16h 45m
    $221–359

Buffalo to Louisville by bus and foot

Calendar7Weekly Services
Duration14h 47mAverage Duration
Ticket$105Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Louisville.ExpandLaunch map view
  • Distance: 511.1 mi
  • Duration: 6h 26m

What companies run services between Buffalo, NY, USA and Louisville, KY, USA?

Delta, Southwest Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Buffalo to Louisville, KY via Columbus, E Main St & S 5Th St, S Grant Ave & E Mound St, Columbus, and Indianapolis Union Station in around 14h 47m.

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