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How to get fromBuffalo to Mayo Clinicby plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus)

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There are 7 ways to get from Buffalo to Mayo Clinic by plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Rochester (RST)plane plane BUF - RST
    7h 7m
    $88–492

  2. Train, bus via Milwaukee

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    21h 7m
    $224–593

  3. Bus

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    21h 8m
    $164–284

  4. Drive  877.3 mi

    1. Drive from Buffalo to Mayo Cliniccar car 877.3 mi
    14h 45m
    $161–232

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Minneapolis–Saint Paul International Airport (MSP)plane plane BUF - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 41m
    $154–604

  6. Train, bus

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    22h 54m
    $260–723

  7. Bus via Detroit

    1. Take the bus from Buffalo to Toronto Pearson Airportbus bus
    2. Take the bus from Toronto Pearson Airport to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    26h 33m
    $165–275

Buffalo to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration21h 7mAverage Duration
Ticket$224Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Mayo Clinic.ExpandLaunch map view
  • Distance: 714.7 mi
  • Duration: 7h 7m

What companies run services between Buffalo, NY, USA and Mayo Clinic, MN, USA?

United Airlines, Delta, and American Airlines fly from Buffalo Niagara International Airport (BUF) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Buffalo to Mayo Clinic via Cleveland Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 21h 8m.

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