Rome2Rio

How to get fromBuffalo to Mechanicsburgby bus (Greyhound), train (Amtrak), car, plane, train, or bus (Flixbus)

Find Transport to Mechanicsburg

See all options

There are 7 ways to get from Buffalo to Mechanicsburg by bus (Greyhound), train (Amtrak), car, plane, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via State College

    best
    1. Take the bus from Buffalo to DuBoisbus bus
    2. Take the bus from DuBois to State Collegebus bus
    3. Take the bus from State College Bus Station to Harrisburg Bus Stationbus bus
    10h 44m
    $80–219

  2. Drive  288.5 mi

    cheapest
    1. Drive from Buffalo to Mechanicsburgcar car 288.5 mi
    5h 45m
    $51–74

  3. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Harrisburgtrain train Keystone Service / ...
    13h 44m
    $344–544

  4. Fly to Philadelphia International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Philadelphia International Airport (PHL)plane plane BUF - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    7h 20m
    $124–524

  5. Bus

    1. Take the bus from Buffalo to DuBoisbus bus
    2. Take the bus from DuBois to State Collegebus bus
    3. Take the bus from State College Regional Airport to Harrisburg Bus Stationbus bus
    10h 49m
    $76–232

  6. Bus #2

    1. Take the bus from Buffalo to Scranton Bus Stationbus bus Greyhound US0215 / ...
    2. Take the bus from Scranton, Pa to Harrisburg, Pabus bus 771
    10h 54m
    $78–154

  7. Fly to Laguardia Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Laguardia Airport (LGA)plane plane BUF - LGA
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Harrisburgtrain train
    8h 56m
    $180–676

Buffalo to Mechanicsburg by bus and foot

Calendar7Weekly Services
Duration10h 44mAverage Duration
Ticket$80Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Buffalo to Mechanicsburg.ExpandLaunch map view
  • Distance: 340.9 mi
  • Duration: 10h 44m

What companies run services between Buffalo, NY, USA and Mechanicsburg, Cumberland County, PA, USA?

You can take a bus from Buffalo to E Main St & Arch St WB via DuBois, State College, State College Bus Station, Harrisburg Bus Station, and Market Square Transfer Center in around 10h 44m. Alternatively, you can take a train from Buffalo to E Main St & Arch St WB via Ny Moynihan Train Hall At Penn Station, Harrisburg, and Market Square Transfer Center in around 13h 44m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There