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How to get fromBuffalo to Mechanicsburgby bus (Greyhound), train (Amtrak), car, plane, train, or bus (Flixbus)

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There are 6 ways to get from Buffalo to Mechanicsburg by bus (Greyhound), train (Amtrak), car, plane, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via State College

    best
    1. Take the bus from Buffalo to DuBoisbus bus
    2. Take the bus from DuBois to State Collegebus bus
    3. Take the bus from State College Bus Station to Harrisburg Bus Stationbus bus
    10h 44m
    $92–183

  2. Drive 287.5 mi

    cheapest
    1. Drive from Buffalo to Mechanicsburgcar car 287.5 mi
    5h 46m
    $53–76

  3. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Harrisburgtrain train Keystone Service / ...
    13h 44m
    $204–418

  4. Fly, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Philadelphia International Airport (PHL)plane plane BUF - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    7h 12m
    $126–703

  5. Bus

    1. Take the bus from Buffalo to DuBoisbus bus
    2. Take the bus from DuBois to State Collegebus bus
    3. Take the bus from State College Regional Airport to Harrisburg Bus Stationbus bus
    10h 49m
    $98–181

  6. Bus #2

    1. Take the bus from Buffalo to Scranton Bus Stationbus bus Greyhound US0215 / ...
    2. Take the bus from Scranton, Pa to Harrisburg, Pabus bus 771
    10h 54m
    $70–162

Buffalo to Mechanicsburg by bus and foot

Calendar14Weekly Services
Duration10h 44mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Mechanicsburg.ExpandLaunch map view
  • Distance: 340.9 mi
  • Duration: 10h 44m

What companies run services between Buffalo, NY, USA and Mechanicsburg, Cumberland County, PA, USA?

You can take a bus from Buffalo to E Main St & Arch St WB via DuBois, State College, State College Bus Station, Harrisburg Bus Station, and Market Square Transfer Center in around 10h 44m. Alternatively, you can take a train from Buffalo to E Main St & Arch St WB via Ny Moynihan Train Hall At Penn Station, Harrisburg, and Market Square Transfer Center in around 13h 44m.

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