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How to get fromBuffalo to Mississippiby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

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There are 7 ways to get from Buffalo to Mississippi by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Memphis

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Memphis (MEM)plane plane BUF - MEM
    5h 37m
    $184–879

  2. Fly to Mobile Regional Airport, bus

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Mobile Regional Airport (MOB)plane plane BUF - MOB
    2. Take the bus from Mobile Bus Station to Biloxi Transit Centerbus bus
    8h 27m
    $135–546

  3. Bus

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Jacksonbus bus
    26h 55m
    $177–299

  4. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Jacksontrain train City of New Orleans
    28h 25m
    $322–883

  5. Drive  1,091.3 mi

    1. Drive from Buffalo to Jacksoncar car 1,091.3 mi
    19h 11m
    $200–288

  6. Fly to Jackson/Vicksburg

    1. Fly from Buffalo Niagara International Airport (BUF) to Jackson/Vicksburg (JAN)plane plane BUF - JAN
    6h 34m
    $137–542

  7. Fly to Gulfport-Biloxi Regional Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Gulfport-Biloxi Regional Airport (GPT)plane plane BUF - GPT
    6h 34m
    $143–666

Buffalo to Mississippi by bus

Calendar7Weekly Buses
Duration26h 55mAverage Duration
Ticket$177Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Mississippi.ExpandLaunch map view
  • Distance: 831.8 mi
  • Duration: 5h 37m

What companies run services between Buffalo, NY, USA and Mississippi, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Memphis (MEM) hourly. Alternatively, you can take a bus from Buffalo to Jackson via Cleveland Bus Station, Nashville Bus Station, and Memphis Bus Station in around 26h 55m.

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