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How to get fromBuffalo to Mount Pleasantby plane, train (Amtrak), bus, car, shuttle, or train

Find Transport to Mount Pleasant

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There are 8 ways to get from Buffalo to Mount Pleasant by plane, train (Amtrak), bus, car, shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Charleston International Airport (CHS)plane plane BUF - CHS
    7h 53m
    $116–632

  2. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    23h 52m
    $413–819

  3. Bus, drive

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to Norfolkbus bus
    3. Take the bus from Norfolk to Myrtle Beach Bus Stationbus bus
    4. Drive from Myrtle Beach Bus Station to S. Pinckney St / Society Rdcar car
    5. Take the bus from S. Pinckney St / Society Rd to East Cooper Medical Centerbus bus
    30h 15m
    $178–346

  4. Drive 862.5 mi

    1. Drive from Buffalo to Mount Pleasantcar car 862.5 mi
    14h 46m
    $158–228

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Charleston International Airport (CHS)plane plane ROC - CHS
    7h 29m
    $173–798

  6. Shuttle to Toronto Pearson International Airport, fly

    1. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Charleston International Airport (CHS)plane plane YYZ - CHS
    10h 22m
    $171–506

  7. Train, bus, drive

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Fayetteville Amtrak Stationtrain train
    3. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    4. Drive from Myrtle Beach Bus Station to S. Pinckney St / Society Rdcar car
    5. Take the bus from S. Pinckney St / Society Rd to Stuart Engals Blvd / Wando Crossing Centerbus bus
    33h 44m
    $379–798

  8. Bus, train, drive

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    4. Drive from Myrtle Beach Bus Station to S. Pinckney St / Society Rdcar car
    5. Take the bus from S. Pinckney St / Society Rd to Stuart Engals Blvd / Wando Crossing Centerbus bus
    37h 58m
    $328–786

Buffalo Niagara International Airport (BUF) to Charleston International Airport (CHS) flights

Calendar120Weekly Planes
Duration4h 51mAverage Duration
Ticket$115Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Mount Pleasant.ExpandLaunch map view
  • Distance: 730.5 mi
  • Duration: 7h 53m

What companies run services between Buffalo, NY, USA and Mount Pleasant, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Charleston International Airport (CHS) hourly. Alternatively, you can take a train from Buffalo to Mount Pleasant via Ny Moynihan Train Hall At Penn Station and Charleston Amtrak Station in around 23h 52m.

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