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How to get fromBuffalo to Murrells Inletby plane, train, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Find Transport to Murrells Inlet

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There are 8 ways to get from Buffalo to Murrells Inlet by plane, train, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR)plane plane BUF - MYR
    5h 32m
    $107–432

  2. Train, bus via Washington

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Washington Union Stationtrain train
    3. Take the train from Washington Union Station to Fayetteville Amtrak Stationtrain train
    4. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    23h 10m
    $598–940

  3. Bus

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    23h 36m
    $216–336

  4. Drive  771.8 mi

    1. Drive from Buffalo to Murrells Inletcar car 771.8 mi
    15h 53m
    $141–204

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Myrtle Beach (MYR)plane plane ROC - MYR
    5h 6m
    $155–583

  6. Bus via Raleigh

    1. Take the bus from Buffalo to Port Authority Bus Terminalbus bus
    2. Take the bus from Port Authority Bus Terminal to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    24h 36m
    $227–513

  7. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Fayetteville Amtrak Stationtrain train
    3. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    24h 45m
    $608–940

  8. Train, drive (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Kingstree Stationtrain train
    3. Drive from Kingstree Station to Murrells Inletcar car
    26h 8m
    $612–987

Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR) flights

Calendar78Weekly Planes
Duration4h 33mAverage Duration
Ticket$69Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Murrells Inlet.ExpandLaunch map view
  • Distance: 664.7 mi
  • Duration: 5h 32m

What companies run services between Buffalo, NY, USA and Murrells Inlet, SC, USA?

Southwest Airlines, American Airlines, and Delta fly from Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR) every 2 hours. Alternatively, you can take a bus from Buffalo to Murrells Inlet via Newark Penn Station, Fayetteville Bus Station, and Myrtle Beach Bus Station in around 23h 36m.

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