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How to get fromBuffalo to Murrells Inletby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus, Greyhound)

Find Transport to Murrells Inlet

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There are 7 ways to get from Buffalo to Murrells Inlet by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR)plane plane BUF - MYR
    5h 22m
    $107–422

  2. Bus via Youngstown

    1. Take the bus from Buffalo, NY to Youngstown, OHbus bus
    2. Take the bus from Youngstown Bus Stop to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Raleigh Bus Stationbus bus
    4. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    22h 46m
    $167–309

  3. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Fayetteville Amtrak Stationtrain train
    3. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    24h 30m
    $301–668

  4. Drive  771.8 mi

    1. Drive from Buffalo to Murrells Inletcar car 771.8 mi
    15h 53m
    $141–204

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Myrtle Beach (MYR)plane plane ROC - MYR
    5h 6m
    $159–641

  6. Train, drive (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Kingstree Stationtrain train
    3. Drive from Kingstree Station to Murrells Inletcar car
    26h 8m
    $278–660

  7. Bus

    1. Take the bus from Buffalo to Ithacabus bus
    2. Take the bus from Ithaca to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Fayetteville Bus Stationbus bus
    4. Take the bus from Fayetteville Bus Station to Myrtle Beach Bus Stationbus bus
    26h 31m
    $209–327

Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR) flights

Calendar89Weekly Planes
Duration5h 24mAverage Duration
Ticket$67Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Murrells Inlet.ExpandLaunch map view
  • Distance: 664.7 mi
  • Duration: 5h 22m

What companies run services between Buffalo, NY, USA and Murrells Inlet, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Myrtle Beach (MYR) hourly. Alternatively, you can take a bus from Buffalo, NY to Murrells Inlet via Youngstown, OH, Youngstown Bus Stop, Washington Union Station, Raleigh Bus Station, and Myrtle Beach Bus Station in around 22h 46m.

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