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How to get fromBuffalo to North Carolinaby plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus, Greyhound)

Find Transport to North Carolina

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There are 8 ways to get from Buffalo to North Carolina by plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Charlotte Douglas International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Charlotte Douglas International Airport (CLT)plane plane BUF - CLT
    4h 8m
    $100–605

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Charlestonbus bus
    3. Take the bus from Charleston to Charlottebus bus
    15h 40m
    $83–196

  3. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Charlotte Amtrak Stationtrain train Crescent / ...
    22h 11m
    $284–728

  4. Drive  654.5 mi

    1. Drive from Buffalo to Charlottecar car 654.5 mi
    11h 11m
    $120–173

  5. Bus to Rochester, fly to Charlotte Douglas International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Charlotte Douglas International Airport (CLT)plane plane ROC - CLT
    5h 21m
    $162–845

  6. Bus to Rochester, fly to Raleigh-Durham International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Raleigh-Durham International Airport (RDU)plane plane ROC - RDU
    5h 49m
    $142–695

  7. Bus to Rochester, fly to Concord

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Concord (USA)plane plane ROC - USA
    5h 18m
    $302–990

  8. Bus via Newark

    1. Take the bus from Buffalo to Newark Penn Stationbus bus FlixBus N2686 / ...
    2. Take the bus from Newark Penn Station to Charlotte Bus Stationbus bus Greyhound US0700 / ...
    21h 20m
    $151–261

Buffalo to North Carolina by bus

Calendar7Weekly Buses
Duration15h 40mAverage Duration
Ticket$83Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to North Carolina.ExpandLaunch map view
  • Distance: 565.8 mi
  • Duration: 4h 8m

What companies run services between Buffalo, NY, USA and North Carolina, USA?

American Airlines, Southwest Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Charlotte Douglas International Airport (CLT) every 3 hours. Alternatively, you can take a bus from Buffalo to Charlotte via Akron and Charleston in around 15h 40m.

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