There are 7 ways to get from Buffalo to Northborough by plane, bus (Greyhound), train (Amtrak), car, train, bus, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Buffalo Niagara International Airport to Worcester Regional Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Worcester Regional Airport (ORH)plane BUF - ORH
5h 50m$106–453Drive 425.3 mi
cheapest- Drive from Buffalo to Northboroughcar 425.3 mi
7h 27m$73–105Bus
- Take the bus from Buffalo to Springfield Union Stationbus Greyhound US0171
- Take the bus from Springfield Union Station to Worcester Union Stationbus Greyhound US0230 / ...
10h 15m$109–161Train (Amtrak)
- Take the train from Buffalo Depew Station to Worcester Union Stationtrain Lake Shore Limited
12h 47m$258–540Fly Buffalo Niagara International Airport to Boston Logan Airport, train
- Fly from Buffalo Niagara International Airport (BUF) to Boston Logan Airport (BOS)plane BUF - BOS
- Take the train from Back Bay to Westboroughtrain
5h 7m$96–458Bus to Rochester, fly to Boston Logan Airport, train
- Take the bus from Buffalo to Rochester Bus Stopbus
- Fly from Rochester (ROC) to Boston Logan Airport (BOS)plane ROC - BOS
- Take the train from Back Bay to Westboroughtrain
6h 36m$140–633Bus via Ithaca
- Take the bus from Buffalo to Ithacabus
- Take the bus from Ithaca to Albany Bus Terminal, NYbus
- Take the bus from Albany Bus Terminal, NY to Worcester Union Stationbus
14h 30m$93–166
Buffalo Niagara International Airport (BUF) to Worcester Regional Airport (ORH) flights
Comparing Your Travel Options
The cheapest way to get from Buffalo to Northborough is to drive which costs $70 - $110 and takes 7h 27m.
The fastest way to get from Buffalo to Northborough is to fly and train which takes 5h 7m and costs $95 - $460.
No, there is no direct bus from Buffalo to Northborough station. However, there are services departing from Buffalo and arriving at Worcester Union Station via Springfield Union Station. The journey, including transfers, takes approximately 10h 15m.
No, there is no direct train from Buffalo to Northborough. However, there are services departing from Buffalo and arriving at Westborough via Buffalo Depew Station and Worcester. The journey, including transfers, takes approximately 12h 47m.
The distance between Buffalo and Northborough is 379 miles. The road distance is 427.8 miles.
The best way to get from Buffalo to Northborough without a car is to bus which takes 10h 15m and costs $100 - $170.
It takes approximately 5h 50m to get from Buffalo to Northborough, including transfers.
Buffalo to Northborough bus services, operated by Greyhound USA, depart from Buffalo station.
Buffalo to Northborough train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo to Northborough is to fly which takes 5h 50m and costs $100 - $460. Alternatively, you can bus, which costs $100 - $170 and takes 10h 15m, you could also train, which costs $250 - $550 and takes 12h 47m.
What companies run services between Buffalo, NY, USA and Northborough, MA, USA?
Delta, American Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Worcester Regional Airport (ORH) 4 times a day. Alternatively, you can take a bus from Buffalo to Northborough via Springfield Union Station and Worcester Union Station in around 10h 15m.
- Website
- aa.com
Flights from Buffalo Niagara International Airport to Worcester Regional Airport via Philadelphia
- Ave. Duration
- 6h 31m
- When
- Tuesday, Wednesday, Friday, and Saturday
- Estimated price
- $65–380
Flights from Buffalo Niagara International Airport to Boston Logan Airport
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- $60–390
Flights from Rochester to Boston Logan Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $80–550
- Website
- jetblue.com
Flights from Buffalo Niagara International Airport to Worcester Regional Airport via Orlando
- Ave. Duration
- 6h 39m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $160–700
Flights from Buffalo Niagara International Airport to Boston Logan Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $60–390
- Website
- delta.com
Flights from Buffalo Niagara International Airport to Worcester Regional Airport via New York La Guardia
- Ave. Duration
- 6h 2m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $60–370
- Website
- southwest.com
Flights from Rochester to Boston Logan Airport via Baltimore
- Ave. Duration
- 3h 50m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $110–650
- Website
- united.com
Flights from Rochester to Boston Logan Airport via Newark
- Ave. Duration
- 3h 53m
- When
- Saturday
- Estimated price
- $90–600
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Buffalo Depew Station to Worcester Union Station
- Ave. Duration
- 10h 25m
- Frequency
- Once daily
- Estimated price
- $240–380
- Website
- Amtrak
Train from Back Bay to Westborough
- Ave. Duration
- 1h 7m
- Frequency
- Hourly
- Estimated price
- $6–12
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $6–12
Train from Back Bay to Westborough
- Ave. Duration
- 1h 7m
- Frequency
- Hourly
- Estimated price
- $6–12
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $6–12
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Buffalo to Springfield Union Station
- Ave. Duration
- 8h 5m
- Frequency
- Twice daily
- Estimated price
- $70–110
- Website
- Greyhound
Bus from Springfield Union Station to Worcester Union Station
- Ave. Duration
- 55 min
- Frequency
- Every 4 hours
- Estimated price
- $9–14
- Website
- Greyhound
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 20m
- Frequency
- Every 4 hours
- Estimated price
- $13–21
- Website
- Greyhound
- Phone
- 1-800-343-9999
- Website
- Peter Pan
Bus from Springfield Union Station to Worcester Union Station
- Ave. Duration
- 1h
- Frequency
- 4 times a day
- Estimated price
- $10–18
- Website
- Peter Pan
Bus from Albany Bus Terminal, NY to Worcester Union Station
- Ave. Duration
- 3h 45m
- Frequency
- 4 times a week
- Estimated price
- $26–50
- Website
- Peter Pan
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Buffalo to Rochester Bus Stop
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- $12–18
- Schedules at
- Flixbus USA
Bus from Buffalo to Ithaca
- Ave. Duration
- 3h 45m
- Frequency
- 3 times a day
- Estimated price
- $26–40
- Schedules at
- Flixbus USA
Bus from Ithaca to Albany Bus Terminal, NY
- Ave. Duration
- 4h 25m
- Frequency
- 6 times a week
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
Bus from Albany Bus Terminal, NY to Worcester Union Station
- Ave. Duration
- 3h 15m
- Frequency
- Once daily
- Estimated price
- $21–35
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
Buffalo to Northborough bus services, operated by Greyhound USA, arrive at Springfield Union Station.
Buffalo to Northborough train services, operated by Amtrak, arrive at Worcester Union Station.
Yes, the driving distance between Buffalo to Northborough is 428 miles. It takes approximately 7h 27m to drive from Buffalo to Northborough.
Book your Buffalo to Northborough bus tickets online with Omio.
There are 120+ hotels available in Northborough.

















