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How to get fromBuffalo to O'Fallonby plane, train, bus (Greyhound), train (Amtrak), car, or bus

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There are 8 ways to get from Buffalo to O'Fallon by plane, train, bus (Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport, train

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    2. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    7h 36m
    $106–606

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Columbusbus bus Bsb 11 / ...
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    18h 42m
    $104–194

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    19h 9m
    $206–616

  4. Drive  727.8 mi

    1. Drive from Buffalo to O'Falloncar car 727.8 mi
    12h 34m
    $133–192

  5. Bus to Rochester, fly, train

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    3. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    8h 50m
    $173–846

  6. Bus to Toronto Pearson International Airport, fly, train

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    3. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    9h 15m
    $109–533

  7. Bus to Cleveland-Hopkins International Airport, fly, train

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    3. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    8h 15m
    $528–956

  8. Bus via Pittsburgh

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    23h 2m
    $150–367

Buffalo to O'Fallon by bus and train

Calendar14Weekly Services
Duration18h 42mAverage Duration
Ticket$104Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to O'Fallon.ExpandLaunch map view
  • Distance: 728.6 mi
  • Duration: 7h 36m

What companies run services between Buffalo, NY, USA and O'Fallon, IL, USA?

You can take a bus from Buffalo to State @ Lincoln Eb via Columbus, St Louis Bus Station, CIVIC CENTER station, FAIRVIEW HEIGHTS station, and Fairview Heights Transit Center in around 18h 42m. Alternatively, you can take a train from Buffalo to Lincoln @ 3Rd Street Nb via Buffalo Depew Station, Chicago Union Station, St. Louis, CIVIC CENTER station, SHILOH-SCOTT station, and Shiloh-Scott Transit Center in around 19h 9m.

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