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How to get fromBuffalo to Panama Cityby plane, car, or bus

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There are 6 ways to get from Buffalo to Panama City by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Northwest Florida Beaches International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Northwest Florida Beaches International Airport (ECP)plane plane BUF - ECP
    5h 53m
    $191–708

  2. Fly Buffalo Niagara International Airport to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Buffalo Niagara International Airport (BUF) to Destin–Fort Walton Beach Airport (VPS)plane plane BUF - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    7h 20m
    $138–646

  3. Drive 1,155 mi

    1. Drive from Buffalo to Panama Citycar car 1,155 mi
    20h
    $211–305

  4. Fly Buffalo Niagara International Airport to Dothan Regional Airport, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Dothan Regional Airport (DHN)plane plane BUF - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama Citycar car
    8h 13m
    $182–602

  5. Bus to Rochester, fly to Northwest Florida Beaches International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Northwest Florida Beaches International Airport (ECP)plane plane ROC - ECP
    7h 38m
    $214–724

  6. Fly Buffalo Niagara International Airport to Tallahassee, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Tallahassee (TLH)plane plane BUF - TLH
    2. Drive from Tallahassee (TLH) to Panama Citycar car
    7h 20m
    $173–804

Buffalo Niagara International Airport (BUF) to Northwest Florida Beaches International Airport (ECP) flights

Calendar61Weekly Planes
Duration5h 57mAverage Duration
Ticket$125Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Panama City.ExpandLaunch map view
  • Distance: 986 mi
  • Duration: 5h 53m

What companies run services between Buffalo, NY, USA and Panama City, FL, USA?

Delta, American Airlines, and Southwest Airlines fly from Buffalo Niagara International Airport (BUF) to Northwest Florida Beaches International Airport (ECP) every 3 hours.

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