Rome2Rio

How to get fromBuffalo to Port Saint Lucieby plane, bus, bus (Flixbus, Greyhound), train, or car

Find Transport to Port Saint Lucie

See all options

There are 7 ways to get from Buffalo to Port Saint Lucie by plane, bus, bus (Flixbus, Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Fort Lauderdale–Hollywood International Airport, bus

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane BUF - FLL
    2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    8h 4m
    $146–623

  2. Bus

    1. Take the bus from Buffalo to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to West Palm Beach Bus Stationbus bus
    3. Take the bus from West Palm Beach Bus Station to Port St Luciebus bus
    35h 44m
    $272–424

  3. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Kissimmee Amtrak Stationtrain train
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    36h 6m
    $874–1,414

  4. Drive  1,267 mi

    1. Drive from Buffalo to Port Saint Luciecar car 1,267 mi
    21h 20m
    $217–313

  5. Fly to Orlando, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Orlando (MCO)plane plane BUF - MCO
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    8h 26m
    $220–452

  6. Fly to Tampa, train, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Tampa (TPA)plane plane BUF - TPA
    2. Take the train from Tampa to Kissimmee Amtrak Stationtrain train
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    11h 27m
    $224–611

  7. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Kissimmee Amtrak Stationtrain train
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    41h 24m
    $733–1,355

Buffalo to Port Saint Lucie by bus

Calendar8Weekly Buses
Duration35h 44mAverage Duration
Ticket$272Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Buffalo to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,275.9 mi
  • Duration: 8h 4m

What companies run services between Buffalo, NY, USA and Port Saint Lucie, FL, USA?

You can take a bus from Buffalo to SW PSL Blvd & SE Bayshore Blvd via Newark Penn Station, West Palm Beach Bus Station, and SW Gatlin Blvd & SW Brescia St in around 35h 44m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound