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How to get fromBuffalo to Port Saint Lucieby plane, bus, bus (Greyhound, Flixbus), train, or car

Find Transport to Port Saint Lucie

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There are 6 ways to get from Buffalo to Port Saint Lucie by plane, bus, bus (Greyhound, Flixbus), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Orlando, bus

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Orlando (MCO)plane plane BUF - MCO
    2. Take the bus from Orlando RedCoach Station to Fort Piercebus bus
    7h 4m
    $172–385

  2. Bus

    1. Take the bus from Buffalo, NY to Youngstown, OHbus bus
    2. Take the bus from Youngstown Bus Stop to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to West Palm Beach Bus Stationbus bus
    4. Take the bus from WPB ITC at BAY D to GATLIN BLVD at I-95 P/R LOTbus bus 95
    35h 49m
    $229–444

  3. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Kissimmee Amtrak Stationtrain train
    3. Take the bus from Kissimmee to Fort Piercebus bus
    36h 10m
    $545–1,079

  4. Drive 1,267.1 mi

    1. Drive from Buffalo to Port Saint Luciecar car 1,267.1 mi
    21h 20m
    $232–334

  5. Fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane BUF - FLL
    2. Take the bus from Fort Lauderdale Airport to Fort Piercebus bus
    6h 54m
    $176–773

  6. Bus, train

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the train from Pittsburgh Amtrak Station to Kissimmee Amtrak Stationtrain train
    3. Take the bus from Kissimmee to Fort Piercebus bus
    41h 28m
    $483–1,105

Buffalo to Port Saint Lucie by bus

Calendar4Weekly Buses
Duration35h 49mAverage Duration
Ticket$229Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,141.8 mi
  • Duration: 7h 4m

What companies run services between Buffalo, NY, USA and Port Saint Lucie, FL, USA?

You can take a bus from Buffalo, NY to SW PSL Blvd & SE Bayshore Blvd via Youngstown, OH, Youngstown Bus Stop, Washington Union Station, West Palm Beach Bus Station, WPB ITC at BAY D, and SW Gatlin Blvd & SW Brescia St in around 35h 49m.

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