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How to get fromBuffalo to Saint Charlesby plane, train (Amtrak), bus (Greyhound), car, bus, or shuttle

Find Transport to Saint Charles

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There are 8 ways to get from Buffalo to Saint Charles by plane, train (Amtrak), bus (Greyhound), car, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    5h 57m
    $160–832

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Columbus - Mound Stbus bus Buffalo
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    19h 8m
    $102–212

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    19h 1m
    $266–679

  4. Drive 751.2 mi

    1. Drive from Buffalo to Saint Charlescar car 751.2 mi
    12h 51m
    $138–198

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    7h 27m
    $184–799

  6. Shuttle to Toronto Pearson International Airport, fly

    1. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    7h 54m
    $190–632

  7. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    7h 17m
    $529–966

  8. Bus via Pittsburgh

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    22h 50m
    $150–397

Buffalo to Saint Charles by train and bus (Amtrak)

Calendar14Weekly Services
Duration19h 1mAverage Duration
Ticket$266Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Saint Charles.ExpandLaunch map view
  • Distance: 697.4 mi
  • Duration: 5h 57m

What companies run services between Buffalo, NY, USA and Saint Charles, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Buffalo to 4375 Rider Trail North Sb via Buffalo Depew Station, Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 19h 1m.

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