Rome2Rio

How to get fromBuffalo to Saint Charlesby plane, train (Amtrak), bus (Greyhound), car, or bus

Find Transport to Saint Charles

See all options

There are 8 ways to get from Buffalo to Saint Charles by plane, train (Amtrak), bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    6h 19m
    $106–606

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Columbusbus bus Bsb 11 / ...
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    19h 3m
    $102–192

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    19h 1m
    $206–617

  4. Drive  751.2 mi

    1. Drive from Buffalo to Saint Charlescar car 751.2 mi
    12h 51m
    $138–198

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    7h 37m
    $174–796

  6. Bus to Toronto Pearson International Airport, fly

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    8h 17m
    $115–523

  7. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    7h 12m
    $529–957

  8. Bus via Pittsburgh

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    22h 50m
    $150–367

Buffalo to Saint Charles by train and bus (Amtrak)

Calendar14Weekly Services
Duration19h 1mAverage Duration
Ticket$206Cheapest Price
See schedules

Questions & Answers

Map of how to get from Buffalo to Saint Charles.ExpandLaunch map view
  • Distance: 699.2 mi
  • Duration: 6h 19m

What companies run services between Buffalo, NY, USA and Saint Charles, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Buffalo to 4375 Rider Trail North Sb via Buffalo Depew Station, Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 19h 1m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers