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How to get fromBuffalo to Saint Charlesby plane, train (Amtrak), bus (Greyhound), car, or bus

Find Transport to Saint Charles

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There are 8 ways to get from Buffalo to Saint Charles by plane, train (Amtrak), bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    6h 53m
    $122–626

  2. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    19h 10m
    $462–848

  3. Bus

    1. Take the bus from Buffalo to Columbusbus bus Bsb 11
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    19h 32m
    $128–222

  4. Drive  751.2 mi

    1. Drive from Buffalo to Saint Charlescar car 751.2 mi
    12h 51m
    $133–192

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    8h 5m
    $200–918

  6. Bus to Toronto Pearson International Airport, fly

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    8h 36m
    $131–563

  7. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    7h 36m
    $160–732

  8. Bus via Pittsburgh

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    23h 14m
    $181–407

Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) flights

Calendar97Weekly Planes
Duration5h 20mAverage Duration
Ticket$104Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Saint Charles.ExpandLaunch map view
  • Distance: 704.8 mi
  • Duration: 6h 53m

What companies run services between Buffalo, NY, USA and Saint Charles, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Buffalo to Saint Charles via Buffalo Depew Station, Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 19h 10m.

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