There are 8 ways to get from Buffalo to Saint Charles by plane, train (Amtrak), bus (Greyhound), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Buffalo Niagara International Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane BUF - STL
6h 19m$106–606Bus
cheapest- Take the bus from Buffalo to Columbusbus Bsb 11 / ...
- Take the bus from Columbus to St Louis Bus Stationbus Greyhound US0421
19h 3m$102–192Train (Amtrak)
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain Lake Shore Limited
- Take the train from Chicago Union Station to St. Louistrain Lincoln Service / ...
19h 1m$206–617Drive 751.2 mi
- Drive from Buffalo to Saint Charlescar 751.2 mi
12h 51m$138–198Bus to Rochester, fly
- Take the bus from Buffalo to Rochester Bus Stopbus
- Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane ROC - STL
7h 37m$174–796Bus to Toronto Pearson International Airport, fly
- Take the bus from Buffalo to Mississaugabus
- Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane YYZ - STL
8h 17m$115–523Bus to Cleveland-Hopkins International Airport, fly
- Take the bus from Buffalo to Cleveland Bus Stationbus
- Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane CLE - STL
7h 12m$529–957Bus via Pittsburgh
- Take the bus from Buffalo, Ny to Pittsburgh, Pabus 530
- Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus Greyhound US0421
22h 50m$150–367
Buffalo to Saint Charles by train and bus (Amtrak)
Questions & Answers
The cheapest way to get from Buffalo to Saint Charles is to bus which costs $100 - $200 and takes 19h 3m.
The fastest way to get from Buffalo to Saint Charles is to fly which takes 6h 19m and costs $100 - $650.
No, there is no direct bus from Buffalo to Saint Charles. However, there are services departing from Buffalo and arriving at 4375 Rider Trail North Sb via Columbus, Civic Center Transit Center and North Hanley Transit Center. The journey, including transfers, takes approximately 19h 3m.
No, there is no direct train from Buffalo to Saint Charles station. However, there are services departing from Buffalo and arriving at NORTH HANLEY station via Buffalo Depew Station, Chicago Union Station and CIVIC CENTER station. The journey, including transfers, takes approximately 19h 1m.
The distance between Buffalo and Saint Charles is 703 miles. The road distance is 755.6 miles.
The best way to get from Buffalo to Saint Charles without a car is to train which takes 19h 1m and costs $200 - $650.
It takes approximately 6h 19m to get from Buffalo to Saint Charles, including transfers.
Buffalo to Saint Charles bus services, operated by Barons Bus, depart from Buffalo station.
Buffalo to Saint Charles train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo to Saint Charles is to fly which takes 6h 19m and costs $100 - $650. Alternatively, you can train, which costs $200 - $650 and takes 19h 1m, you could also bus, which costs $100 - $200 and takes 19h 3m.
What companies run services between Buffalo, NY, USA and Saint Charles, MO, USA?
Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Buffalo to 4375 Rider Trail North Sb via Buffalo Depew Station, Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 19h 1m.
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 4h 1m
- When
- Tuesday to Saturday
- Estimated price
- $110–600
Flights from Buffalo Niagara International Airport to Lambert–St. Louis International Airport via Baltimore
- Ave. Duration
- 5h 32m
- When
- Every day
- Estimated price
- $130–700
Flights from Buffalo Niagara International Airport to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 5h 6m
- When
- Sunday, Tuesday, Wednesday, Monday, Thursday, and Friday
- Estimated price
- $120–650
Flights from Rochester to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 4h 16m
- When
- Every day
- Estimated price
- $140–750
Flights from Rochester to Lambert–St. Louis International Airport via Baltimore
- Ave. Duration
- 5h 23m
- When
- Every day
- Estimated price
- $170–850
Flights from Cleveland-Hopkins International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $100–600
Flights from Cleveland-Hopkins International Airport to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 3h 33m
- When
- Tuesday to Saturday
- Estimated price
- $100–650
Flights from Cleveland-Hopkins International Airport to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 3h 50m
- When
- Monday, Thursday, Friday, Sunday, and Saturday
- Estimated price
- $120–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Buffalo Depew Station to Chicago Union Station
- Ave. Duration
- 10h 33m
- Frequency
- Twice daily
- Estimated price
- $130–310
- Website
- Amtrak
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $70–170
- Website
- Amtrak
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Buffalo to Columbus
- Ave. Duration
- 7h
- Frequency
- Twice daily
- Estimated price
- $35–80
- Website
- Barons Bus
Want to know more about travelling around United States
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More Questions & Answers
Buffalo to Saint Charles bus services, operated by Barons Bus, arrive at Columbus station.
Saint Charles is 1h behind Buffalo. It is currently 10:28 PM in Buffalo and 9:28 PM in Saint Charles.
Buffalo to Saint Charles train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Buffalo to Saint Charles is 756 miles. It takes approximately 12h 51m to drive from Buffalo to Saint Charles.
There are 233+ hotels available in Saint Charles.









